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Literature summary extracted from
- Interaction of human protein disulfide isomerase and human P5 with drug compounds: Analysis using biosensor technology (2008), Process Biochem., 43, 1330-1337.
No PubMed abstract available
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.3.4.1 | expression in Escherichia coli | Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | additional information | analysis of binding and dissociation constants of various antibiotics with PDI and PDI domain deletion mutants lacking domains abb', domains b'a'c, domains aba'c | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.4.1 | gentamycin | analysis of binding and dissociation constants with PDI and PDI domain deletion mutants | Homo sapiens |  |
| 5.3.4.1 | kanamycin | analysis of binding and dissociation constants with PDI and PDI domain deletion mutants | Homo sapiens | |
| 5.3.4.1 | neomycin | analysis of binding and dissociation constants with PDI and PDI domain deletion mutants | Homo sapiens | |
| 5.3.4.1 | paromomycin | analysis of binding and dissociation constants with PDI and PDI domain deletion mutants | Homo sapiens | |
| 5.3.4.1 | ribostamycin | analysis of binding and dissociation constants with PDI and PDI domain deletion mutants | Homo sapiens | |
| 5.3.4.1 | sisomycin | analysis of binding and dissociation constants with PDI and PDI domain deletion mutants | Homo sapiens | |
| 5.3.4.1 | streptomycin | analysis of binding and dissociation constants with PDI and PDI domain deletion mutants | Homo sapiens | |
| 5.3.4.1 | Vancomycin | analysis of binding and dissociation constants with PDI and PDI domain deletion mutants | Homo sapiens | |
| 5.3.4.1 | vincristine | inhibits chaperone activity but not isomerase activity of both isoforms PDI and P5 in vitro. A 100:1 molar ratio of vincristine to enzyme is sufficient to almost completely inhibit chaperone activity | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.4.1 | Homo sapiens | - |
isoform PDI | - |
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Release 2023.1 (January 2023)
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