EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.1 | D-galactose | - |
Ophiorrhiza pumila | |
5.6.2.1 | D-galactose | - |
Camptotheca acuminata | |
5.6.2.1 | D-galactose | - |
Homo sapiens | |
5.6.2.1 | D-galactose | - |
Ophiorrhiza liukiuensis | |
5.6.2.1 | D-galactose | - |
Ophiorrhiza japonica | |
5.6.2.1 | D-galactose | - |
Arabidopsis thaliana | |
5.6.2.1 | D-glucose | - |
Ophiorrhiza pumila | |
5.6.2.1 | D-glucose | - |
Camptotheca acuminata | |
5.6.2.1 | D-glucose | - |
Homo sapiens | |
5.6.2.1 | D-glucose | - |
Ophiorrhiza liukiuensis | |
5.6.2.1 | D-glucose | - |
Ophiorrhiza japonica | |
5.6.2.1 | D-glucose | - |
Arabidopsis thaliana |
EC Number | Application | Comment | Organism |
---|---|---|---|
5.6.2.1 | drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Catharanthus roseus |
5.6.2.1 | drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Ophiorrhiza pumila |
5.6.2.1 | drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Camptotheca acuminata |
5.6.2.1 | drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Ophiorrhiza liukiuensis |
5.6.2.1 | drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Ophiorrhiza japonica |
5.6.2.1 | drug development | comparison of the target sites in plants exploited for obtaining additional information on drug-target interaction and for designing advanced drugs to prevent resistance in cancer cells and combat drug resistance | Arabidopsis thaliana |
EC Number | Cloned (Comment) | Organism |
---|---|---|
5.6.2.1 | expressed in Saccharomyces cerevisiae | Catharanthus roseus |
5.6.2.1 | expressed in Saccharomyces cerevisiae | Ophiorrhiza japonica |
5.6.2.1 | expressed in Saccharomyces cerevisiae | Arabidopsis thaliana |
5.6.2.1 | heterologously expressed in Escherichia coli exhibits topoisomerase activity | Ophiorrhiza pumila |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
5.6.2.1 | I420V | prepared by PCR-based mutagenesis | Ophiorrhiza japonica |
5.6.2.1 | L530I | prepared by PCR-based mutagenesis | Ophiorrhiza japonica |
5.6.2.1 | N421K | prepared by PCR-based mutagenesis | Ophiorrhiza japonica |
5.6.2.1 | N722S | prepared by PCR-based mutagenesis | Ophiorrhiza japonica |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.6.2.1 | camptothecin | - |
Arabidopsis thaliana | |
5.6.2.1 | camptothecin | - |
Camptotheca acuminata | |
5.6.2.1 | camptothecin | - |
Catharanthus roseus | |
5.6.2.1 | camptothecin | - |
Homo sapiens | |
5.6.2.1 | camptothecin | - |
Ophiorrhiza japonica | |
5.6.2.1 | camptothecin | - |
Ophiorrhiza liukiuensis | |
5.6.2.1 | camptothecin | - |
Ophiorrhiza pumila |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.6.2.1 | Arabidopsis thaliana | P30181 | - |
- |
5.6.2.1 | Camptotheca acuminata | - |
camptothecin producing plant | - |
5.6.2.1 | Catharanthus roseus | - |
camptothecin non producing plant | - |
5.6.2.1 | Homo sapiens | P11387 | - |
- |
5.6.2.1 | Ophiorrhiza japonica | - |
camptothecin non producing plant | - |
5.6.2.1 | Ophiorrhiza liukiuensis | - |
camptothecin producing plant has Top1s with point mutations that confer resistance to camptothecin, suggesting the effect of an endogenous toxic metabolite on the evolution of the target cellular component | - |
5.6.2.1 | Ophiorrhiza pumila | - |
camptothecin producing plant | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
5.6.2.1 | hairy root | - |
Ophiorrhiza pumila | - |
5.6.2.1 | hairy root | - |
Ophiorrhiza liukiuensis | - |
5.6.2.1 | leaf | young | Catharanthus roseus | - |
5.6.2.1 | leaf | young | Camptotheca acuminata | - |
5.6.2.1 | leaf | young | Ophiorrhiza japonica | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
5.6.2.1 | AtTop1 | - |
Arabidopsis thaliana |
5.6.2.1 | Ca-Top1 | - |
Camptotheca acuminata |
5.6.2.1 | CrTop1 | - |
Catharanthus roseus |
5.6.2.1 | HsTop1 | - |
Homo sapiens |
5.6.2.1 | human Top1 | - |
Homo sapiens |
5.6.2.1 | OjTop1 | - |
Ophiorrhiza japonica |
5.6.2.1 | OlTop1 | - |
Ophiorrhiza liukiuensis |
5.6.2.1 | OpTop1 | - |
Ophiorrhiza pumila |
5.6.2.1 | Top1 | - |
Catharanthus roseus |
5.6.2.1 | Top1 | - |
Ophiorrhiza pumila |
5.6.2.1 | Top1 | - |
Camptotheca acuminata |
5.6.2.1 | Top1 | - |
Homo sapiens |
5.6.2.1 | Top1 | - |
Ophiorrhiza liukiuensis |
5.6.2.1 | Top1 | - |
Ophiorrhiza japonica |
5.6.2.1 | Top1 | - |
Arabidopsis thaliana |
5.6.2.1 | Topoisomerase I | - |
Catharanthus roseus |
5.6.2.1 | Topoisomerase I | - |
Ophiorrhiza pumila |
5.6.2.1 | Topoisomerase I | - |
Camptotheca acuminata |
5.6.2.1 | Topoisomerase I | - |
Homo sapiens |
5.6.2.1 | Topoisomerase I | - |
Ophiorrhiza liukiuensis |
5.6.2.1 | Topoisomerase I | - |
Ophiorrhiza japonica |
5.6.2.1 | Topoisomerase I | - |
Arabidopsis thaliana |