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Literature summary extracted from

  • Guo, R.; Wan, C.K.; Carpenter, J.H.; Mousallem, T.; Boustany, R.M.; Kuan, C.T.; Burks, A.W.; Zhong, X.P.
    Synergistic control of T cell development and tumor suppression by diacylglycerol kinase alpha and zeta (2008), Proc. Natl. Acad. Sci. USA, 105, 11909-11914.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.107 additional information generation of mice lacking both diacylglycerol kinase alpha and zeat. Absence of both diacylglycerol kinases results in a severe decrease in the number of CD4+CD8- and CD4-CD8+ single-positive thymocytes correlating with increased diacylglycerol kinase-mediated signaling. Positive selection, but not negative selection, is impaired in diacylglycerol kinase alpha-/- zeta -/- mice. The developmental blockage in diacylglycerol kinase alpha-/- zeta -/- mice can be partially overcome by treatment with phosphatidic acid. Decreased diacylglycerol kinase activity also promotes thymic lymphomagenesis accompanying elevated Ras and Erk1/2 activation Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.107 additional information Mus musculus diacylglycerol kinases alpha and zeta synergistically promote T cell maturation in the thymus ?
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Organism

EC Number Organism UniProt Comment Textmining
2.7.1.107 Mus musculus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.107 additional information diacylglycerol kinases alpha and zeta synergistically promote T cell maturation in the thymus Mus musculus ?
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