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Literature summary extracted from

  • Yuan, J.; Palioura, S.; Salazar, J.C.; Su, D.; O'Donoghue, P.; Hohn, M.J.; Cardoso, A.M.; Whitman, W.B.; Söll, D.
    RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea (2006), Proc. Natl. Acad. Sci. USA, 103, 18923-18927.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.164
-
 Methanocaldococcus jannaschii
2.9.1.2
-
 Homo sapiens
2.9.1.2
-
 Methanococcus maripaludis
2.9.1.2
-
 Methanocaldococcus jannaschii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.164 ATP + seryl-tRNASec Methanocaldococcus jannaschii L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) ADP + O-phospho-L-seryl-tRNASec
-
 ?
2.7.1.164 ATP + seryl-tRNASec Methanocaldococcus jannaschii DSM 2661 L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) ADP + O-phospho-L-seryl-tRNASec
-
 ?
2.9.1.2 O-phospho-L-seryl-tRNASec + selenophosphate Methanococcus maripaludis L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.2 O-phospho-L-seryl-tRNASec + selenophosphate Methanocaldococcus jannaschii L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.2 O-phospho-L-seryl-tRNASec + selenophosphate Homo sapiens L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase L-selenocysteinyl-tRNASec + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.164 Methanocaldococcus jannaschii Q58933
-
-
2.7.1.164 Methanocaldococcus jannaschii DSM 2661 Q58933
-
-
2.9.1.2 Homo sapiens Q9HD40
-
-
2.9.1.2 Methanocaldococcus jannaschii Q58027
-
-
2.9.1.2 Methanococcus maripaludis Q6LZM9
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.9.1.2 recombinant enzyme Homo sapiens
2.9.1.2 recombinant enzyme Methanococcus maripaludis
2.9.1.2 recombinant enzyme Methanocaldococcus jannaschii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.164 ATP + L-seryl-tRNASec L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanocaldococcus jannaschii ADP + O-phospho-L-seryl-tRNASec
-
 ?
2.7.1.164 ATP + L-seryl-tRNASec L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanocaldococcus jannaschii DSM 2661 ADP + O-phospho-L-seryl-tRNASec
-
 ?
2.7.1.164 ATP + seryl-tRNASec L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanocaldococcus jannaschii ADP + O-phospho-L-seryl-tRNASec
-
 ?
2.7.1.164 ATP + seryl-tRNASec L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanocaldococcus jannaschii DSM 2661 ADP + O-phospho-L-seryl-tRNASec
-
 ?
2.9.1.2 O-phospho-L-seryl-tRNASec + selenophosphate
-
 Homo sapiens L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.2 O-phospho-L-seryl-tRNASec + selenophosphate
-
 Methanococcus maripaludis L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.2 O-phospho-L-seryl-tRNASec + selenophosphate
-
 Methanocaldococcus jannaschii L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.2 O-phospho-L-seryl-tRNASec + selenophosphate L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanococcus maripaludis L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.2 O-phospho-L-seryl-tRNASec + selenophosphate L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous Ser-tRNASec to O-phosphoseryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase (SepSecS) Methanocaldococcus jannaschii L-selenocysteinyl-tRNASec + phosphate
-
 ?
2.9.1.2 O-phospho-L-seryl-tRNASec + selenophosphate L-phosphoseryl-tRNA is the crucial precursor for L-selenocysteinyl-tRNA formation in archaea and eukarya. Selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase Homo sapiens L-selenocysteinyl-tRNASec + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.164 O-phosphoseryl-tRNASec kinase
-
 Methanocaldococcus jannaschii
2.7.1.164 PSTK
-
 Methanocaldococcus jannaschii
2.9.1.2 SepSecS
-
 Homo sapiens
2.9.1.2 SepSecS
-
 Methanococcus maripaludis
2.9.1.2 SepSecS
-
 Methanocaldococcus jannaschii
2.9.1.2 SLA/LP
-
 Homo sapiens
2.9.1.2 SLA/LP
-
 Methanococcus maripaludis
2.9.1.2 SLA/LP
-
 Methanocaldococcus jannaschii

Cofactor

EC Number Cofactor Comment Organism Structure
2.9.1.2 pyridoxal 5'-phosphate the enzyme needs pyridoxal 5'-phosphate to carry out the conversion of O-phosphoserine to selenocysteine Homo sapiens
2.9.1.2 pyridoxal 5'-phosphate the enzyme needs pyridoxal 5'-phosphate to carry out the conversion of O-phosphoserine to selenocysteine Methanococcus maripaludis
2.9.1.2 pyridoxal 5'-phosphate the enzyme needs pyridoxal 5'-phosphate to carry out the conversion of O-phosphoserine to selenocysteine Methanocaldococcus jannaschii