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Literature summary extracted from

  • Santel, T.; Pflug, G.; Hemdan, N.Y.; Schaefer, A.; Hollenbach, M.; Buchold, M.; Hintersdorf, A.; Lindner, I.; Otto, A.; Bigl, M.; Oerlecke, I.; Hutschenreuter, A.; Sack, U.; Huse, K.; Groth, M.; Birkemeyer, C.; Schellenberger, W.; Gebhardt, R.; Platzer, M.; Weiss, T.; Vijayalakshmi, M.A.; Krueger, M.
    Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity (2008), PLoS ONE, 3, e3508.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.4.1.5 curcumin competitve inhibition, structually related to glutathione, Dixon plot analysis, pH 7.0, 30°C, more efficient inhibition of GLO1 compared to quercetin, myricetin, kaempferol, luteolin, or rutin as inhibitor, results in a decrease of D-lactate release Homo sapiens
4.4.1.5 kaempferol competitve inhibition, structually related to glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, pH 7.0, 30°C, results in a decrease of D-lactate release Homo sapiens
4.4.1.5 luteolin competitve inhibition, structually related to glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, pH 7.0, 30°C, results in a decrease of D-lactate release Homo sapiens
4.4.1.5 myricetin competitve inhibition, structually related to glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, pH 7.0, 30°C, results in a decrease of D-lactate release Homo sapiens
4.4.1.5 quercetin competitve inhibition, structually related to glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, pH 7.0, 30°C, results in a decrease of D-lactate release Homo sapiens
4.4.1.5 rutin competitve inhibition, structually related to glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, pH 7.0, 30°C, results in a decrease of D-lactate release Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.4.1.5 cytosol
-
 Homo sapiens 5829
-

Organism

EC Number Organism UniProt Comment Textmining
4.4.1.5 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.4.1.5 from erythrocytes, purity above 90% Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.4.1.5 1321-N1 cell 1321N1 cell Homo sapiens
-
4.4.1.5 1321-N1 cell brain astrocytoma cell Homo sapiens
-
4.4.1.5 breast cancer cell MDA-MD-231 cell, JIMT-1 cell Homo sapiens
-
4.4.1.5 erythrocyte
-
 Homo sapiens
-
4.4.1.5 JIMT-1 cell breast cancer cell Homo sapiens
-
4.4.1.5 MDA-MB-231 cell breast cancer cell Homo sapiens
-
4.4.1.5 PC-3 cell prostate cancer cell Homo sapiens
-
4.4.1.5 prostate cancer cell PC-3 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
4.4.1.5 0.4
-
 breast cancer cell MDA-MD-231 cell, pH 7.0, 30°C Homo sapiens
4.4.1.5 0.9
-
 brain astrocytoma 1321N1 cell, pH 7.0, 30°C Homo sapiens
4.4.1.5 1.17
-
 breast cancer cell JIMT-1 cell, pH 7.0, 30°C Homo sapiens
4.4.1.5 1.4
-
 prostate cancer cell PC-3 cell, pH 7.0, 30°C Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.4.1.5 30
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.4.1.5 7
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.4.1.5 0.0051
-
 curcumin in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, competitive inhibition, pH 7.0, 30°C Homo sapiens
4.4.1.5 0.013
-
 myricetin in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, competitive inhibition, pH 7.0, 30°C Homo sapiens
4.4.1.5 0.021
-
 kaempferol in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, competitive inhibition, pH 7.0, 30°C Homo sapiens
4.4.1.5 0.023
-
 quercetin in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, competitive inhibition, pH 7.0, 30°C Homo sapiens
4.4.1.5 0.035
-
 luteolin in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, competitive inhibition, pH 7.0, 30°C Homo sapiens
4.4.1.5 0.14
-
 rutin in the presence of increasing amounts of inhibitor at different concentrations of the substrates methylglyoxal and glutathione, Dixon plot analysis, significantly lower inhibition than that with curcumin, competitive inhibition, pH 7.0, 30°C Homo sapiens