BRENDA - Enzyme Database

Protein plasticity: a single amino acid substitution in the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase generates protosta-13(17),24-dien-3beta-ol, a rearrangement product

Wu, T.K.; Wen, H.Y.; Chang, C.H.; Liu, Y.T.; Org. Lett. 10, 2529-2532 (2008)

Data extracted from this reference:

Engineering
EC Number
Protein Variants
Commentary
Organism
5.4.99.7
F699C
inactive
Saccharomyces cerevisiae
5.4.99.7
F699Q
inactive
Saccharomyces cerevisiae
5.4.99.7
F699S
inactive
Saccharomyces cerevisiae
5.4.99.7
F699T
the mutant produces protosta-13(17),24-dien-3beta-ol from (S)-2,3-oxidosqualene
Saccharomyces cerevisiae
5.4.99.7
F699Y
inactive
Saccharomyces cerevisiae
Organism
EC Number
Organism
UniProt
Commentary
Textmining
5.4.99.7
Saccharomyces cerevisiae
-
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
5.4.99.7
(S)-2,3-oxidosqualene
-
694523
Saccharomyces cerevisiae
lanosterol
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
5.4.99.7
ERG7
-
Saccharomyces cerevisiae
5.4.99.7
OSC
-
Saccharomyces cerevisiae
5.4.99.7
Oxidosqualene-lanosterol cyclase
-
Saccharomyces cerevisiae
Engineering (protein specific)
EC Number
Protein Variants
Commentary
Organism
5.4.99.7
F699C
inactive
Saccharomyces cerevisiae
5.4.99.7
F699Q
inactive
Saccharomyces cerevisiae
5.4.99.7
F699S
inactive
Saccharomyces cerevisiae
5.4.99.7
F699T
the mutant produces protosta-13(17),24-dien-3beta-ol from (S)-2,3-oxidosqualene
Saccharomyces cerevisiae
5.4.99.7
F699Y
inactive
Saccharomyces cerevisiae
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
5.4.99.7
(S)-2,3-oxidosqualene
-
694523
Saccharomyces cerevisiae
lanosterol
-
-
-
?