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Literature summary extracted from

  • Erixon, K.M.; Dabalos, C.L.; Leeper, F.J.
    Synthesis and biological evaluation of pyrophosphate mimics of thiamine pyrophosphate based on a triazole scaffold (2008), Org. Biomol. Chem., 6, 3561-3572.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.1.1.1 ([2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethoxy]hydroxyphosphoryldifluoromethyl)phosphonic acid
-
 Zymomonas mobilis
4.1.1.1 ([2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethoxy]hydroxyphosphorylmethyl) phosphonic acid
-
 Zymomonas mobilis
4.1.1.1 2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethanol
-
 Zymomonas mobilis
4.1.1.1 2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl diphosphate
-
 Zymomonas mobilis
4.1.1.1 2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-5-methyl-1H-[1,2,3]triazol-4-yl]ethyl diphosphate
-
 Zymomonas mobilis
4.1.1.1 mono(2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl) iminodiacetate
-
 Zymomonas mobilis
4.1.1.1 mono[2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl] malonate
-
 Zymomonas mobilis
4.1.1.1 N-([2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethoxy]sulfonyl)phosphoramidic acid
-
 Zymomonas mobilis
4.1.1.1 O-2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl sulfamate
-
 Zymomonas mobilis

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.1 Zymomonas mobilis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.1 pyruvate
-
 Zymomonas mobilis acetaldehyde + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.1 PDC
-
 Zymomonas mobilis

Cofactor

EC Number Cofactor Comment Organism Structure
4.1.1.1 thiamine diphosphate dependent on Zymomonas mobilis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
4.1.1.1 0.00000002
-
 2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-5-methyl-1H-[1,2,3]triazol-4-yl]ethyl diphosphate
-
 Zymomonas mobilis
4.1.1.1 0.00000003
-
 2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl diphosphate
-
 Zymomonas mobilis
4.1.1.1 0.00000095
-
 ([2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethoxy]hydroxyphosphoryldifluoromethyl)phosphonic acid
-
 Zymomonas mobilis
4.1.1.1 0.0000012
-
 ([2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethoxy]hydroxyphosphorylmethyl) phosphonic acid
-
 Zymomonas mobilis
4.1.1.1 0.00014
-
 N-([2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethoxy]sulfonyl)phosphoramidic acid
-
 Zymomonas mobilis
4.1.1.1 0.008
-
 O-2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl sulfamate
-
 Zymomonas mobilis
4.1.1.1 0.3
-
 2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethanol
-
 Zymomonas mobilis
4.1.1.1 0.4
-
 mono[2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl] malonate
-
 Zymomonas mobilis
4.1.1.1 0.4
-
 mono(2-[1-(4-amino-2-methylpyrimidin-5-ylmethyl)-1H-[1,2,3]triazol-4-yl]ethyl) iminodiacetate
-
 Zymomonas mobilis