Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Giovannetti, E.; Backus, H.H.; Wouters, D.; Peters, G.J.
    Functional inactivity and mutations of p53 differentially affect sensitivity to 5-fluorouracil and antifolate inhibitors of thymidylate synthase (TS) by altering TS levels in colorectal cancer cells (2008), Nucleosides Nucleotides Nucleic Acids, 27, 740-745.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.45 5-fluorouracil transfection with p53 induces resistance to 5-fluorouracil Homo sapiens
2.1.1.45 GW1843U89
-
 Homo sapiens
2.1.1.45 nolatrexed transfection with p53 induces resistance to nolatrexed Homo sapiens
2.1.1.45 pemetrexed transfection with p53 induces resistance to pemetrexed Homo sapiens
2.1.1.45 raltitrexed transfection with p53 induces resistance to raltitrexed Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP Homo sapiens thymidylate synthase is a key enzyme in the de novo synthesis of dTMP 7,8-dihydrofolate + dTMP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.45 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.45 colorectal cancer cell
-
 Homo sapiens
-
2.1.1.45 Lovo-175X2 cell colorectal cancer cell, mutated subline of Lovo-92 cell Homo sapiens
-
2.1.1.45 Lovo-273X17 cell colorectal cancer cell, mutated subline of Lovo-92 cell Homo sapiens
-
2.1.1.45 Lovo-92 cell wildtype p53 colorectal cancer cell Homo sapiens
-
2.1.1.45 Lovo-li cell colorectal cancer cell harboring a functionally inactive p53 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP
-
 Homo sapiens 7,8-dihydrofolate + dTMP
-
 ?
2.1.1.45 5,10-methylenetetrahydrofolate + dUMP thymidylate synthase is a key enzyme in the de novo synthesis of dTMP Homo sapiens 7,8-dihydrofolate + dTMP
-
 ?