EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.1.1.23 | 6-aminouridine 5'-monophosphate | - |
Homo sapiens | |
4.1.1.23 | 6-aminouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
4.1.1.23 | 6-aminouridine 5'-monophosphate | - |
Plasmodium falciparum | |
4.1.1.23 | 6-aminouridine 5'-monophosphate | - |
Staphylococcus aureus | |
4.1.1.23 | 6-azidouridine 5'-monophosphate | - |
Homo sapiens | |
4.1.1.23 | 6-azidouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
4.1.1.23 | 6-azidouridine 5'-monophosphate | - |
Plasmodium falciparum | |
4.1.1.23 | 6-azidouridine 5'-monophosphate | - |
Staphylococcus aureus | |
4.1.1.23 | 6-cyanouridine 5'-monophosphate | - |
Homo sapiens | |
4.1.1.23 | 6-cyanouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
4.1.1.23 | 6-cyanouridine 5'-monophosphate | - |
Plasmodium falciparum | |
4.1.1.23 | 6-cyanouridine 5'-monophosphate | - |
Staphylococcus aureus | |
4.1.1.23 | 6-iodouridine 5'-monophosphate | - |
Helicobacter pylori | |
4.1.1.23 | 6-iodouridine 5'-monophosphate | - |
Homo sapiens | |
4.1.1.23 | 6-iodouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
4.1.1.23 | 6-iodouridine 5'-monophosphate | - |
Plasmodium falciparum | |
4.1.1.23 | 6-iodouridine 5'-monophosphate | - |
Staphylococcus aureus | |
4.1.1.23 | 6-methyl-uridine | - |
Plasmodium falciparum |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.23 | Orotidine 5'-phosphate | Staphylococcus aureus | - |
UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | Homo sapiens | - |
UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | Helicobacter pylori | - |
UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | Plasmodium falciparum | - |
UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | Methanothermobacter thermautotrophicus | - |
UMP + CO2 | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.1.1.23 | Helicobacter pylori | - |
- |
- |
4.1.1.23 | Homo sapiens | - |
- |
- |
4.1.1.23 | Methanothermobacter thermautotrophicus | O26232 | - |
- |
4.1.1.23 | Plasmodium falciparum | - |
- |
- |
4.1.1.23 | Staphylococcus aureus | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.1.1.23 | 6-cyanouridine 5'-monophosphate | pseudohydrolysis process | Staphylococcus aureus | 6-hydroxyuridine 5'-monophosphate + CN- | - |
? | |
4.1.1.23 | 6-cyanouridine 5'-monophosphate | pseudohydrolysis process | Homo sapiens | 6-hydroxyuridine 5'-monophosphate + CN- | - |
? | |
4.1.1.23 | 6-cyanouridine 5'-monophosphate | pseudohydrolysis process | Plasmodium falciparum | 6-hydroxyuridine 5'-monophosphate + CN- | - |
? | |
4.1.1.23 | 6-cyanouridine 5'-monophosphate | pseudohydrolysis process | Methanothermobacter thermautotrophicus | 6-hydroxyuridine 5'-monophosphate + CN- | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | - |
Staphylococcus aureus | UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | - |
Homo sapiens | UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | - |
Helicobacter pylori | UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | - |
Plasmodium falciparum | UMP + CO2 | - |
? | |
4.1.1.23 | Orotidine 5'-phosphate | - |
Methanothermobacter thermautotrophicus | UMP + CO2 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.1.1.23 | ODCase | - |
Staphylococcus aureus |
4.1.1.23 | ODCase | - |
Homo sapiens |
4.1.1.23 | ODCase | - |
Helicobacter pylori |
4.1.1.23 | ODCase | - |
Plasmodium falciparum |
4.1.1.23 | ODCase | - |
Methanothermobacter thermautotrophicus |
4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Staphylococcus aureus |
4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Homo sapiens |
4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Helicobacter pylori |
4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Plasmodium falciparum |
4.1.1.23 | Orotidine-5'-monophosphate decarboxylase | - |
Methanothermobacter thermautotrophicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
4.1.1.23 | 0.00019 | - |
6-azidouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
4.1.1.23 | 0.00084 | - |
6-aminouridine 5'-monophosphate | - |
Methanothermobacter thermautotrophicus | |
4.1.1.23 | 0.002 | - |
6-azidouridine 5'-monophosphate | - |
Plasmodium falciparum |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
4.1.1.23 | 0.0044 | - |
chloroquine-resistant strain | Plasmodium falciparum | 6-iodouridine 5'-monophosphate | |
4.1.1.23 | 0.0062 | - |
chloroquine-sensitive strain | Plasmodium falciparum | 6-iodouridine 5'-monophosphate | |
4.1.1.23 | 0.5305 | - |
- |
Plasmodium falciparum | 6-methyl-uridine |