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Literature summary extracted from
- Acid sphingomyelinase overexpression enhances the antineoplastic effects of irradiation in vitro and in vivo (2008), Mol. Ther., 16, 1565-1571.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 3.1.4.12 | medicine | recombinant human ASM has little or no effect on the growth of tumor cells at pH 7.4 even in combination with irradiation, however when the culture media is acidified to pH 6.5 to mimic the acidic microenvironment of solid tumors, ASM-mediated cell death is markedly enhanced when combined with irradiation | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.4.12 | expressed in Mus musculus B16-F10 melanoma cells | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.12 | Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.12 | sphingomyelin + H2O | - |
Homo sapiens | N-acylsphingosine + choline phosphate | - |
? |  |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.1.4.12 | acid sphingomyelinase | - |
Homo sapiens |
| 3.1.4.12 | aSMase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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