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Literature summary extracted from

  • Clarke, C.J.; Guthrie, J.M.; Hannun, Y.A.
    Regulation of neutral sphingomyelinase-2 (nSMase2) by tumor necrosis factor-alpha involves protein kinase C-delta in lung epithelial cells (2008), Mol. Pharmacol., 74, 1022-1032.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 additional information phorbol 12-myristate 13-acetate does not increase in vitro N-SMase activity protein kinase C-delta does not regulate tumor necrosis factor-induced N-SMase activity Homo sapiens
3.1.4.12 tumor necrosis factor induces N-SMase activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 Golgi apparatus
-
 Homo sapiens 5794
-
3.1.4.12 plasma membrane phorbol 12-myristate 13-acetate induces nSMase2 translocation to the plasma membrane in a time- and dose-dependent manner, rottlerin inhibits nSMase2 translocation in response to tumor necrosis factor and phorbol 12-myristate 13-acetate Homo sapiens 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.12 Mg2+ dependent on Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 A-549 cell
-
 Homo sapiens
-
3.1.4.12 lung epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 choline-methyl-sphingomyelin + H2O
-
 Homo sapiens ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 N-SMase
-
 Homo sapiens
3.1.4.12 neutral sphingomyelinase
-
 Homo sapiens
3.1.4.12 neutral sphingomyelinase-2
-
 Homo sapiens
3.1.4.12 nSMase2
-
 Homo sapiens