EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.1.45 | medicine | the combination of the oral fluorouracil S-1 and the epidermal growth factor receptor-tyrosine kinase inhibitor gefitinib in shows a synergistic antiproliferative effect in vitro in all non-small cell lung cancer cell lines tested. Gefitinib inhibits the expression of the transcription factor E2F-1, resulting in the down-regulation of thymidylate synthase at the mRNA and protein levels | Homo sapiens |
2.1.1.45 | medicine | thymidylate synthase is a target in the treatment of cancer | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.45 | 5-fluorouracil | - |
Homo sapiens | |
2.1.1.45 | gefitinib | inhibits the expression of the transcription factor E2F-1, resulting in a down-regulation of thymidylate synthase at the mRNA and protein level; inhibits the expression of the transcription factor E2F-1, resulting in the down-regulation of thymidylate synthase at the mRNA and protein levels | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | Homo sapiens | - |
7,8-dihydrofolate + dTMP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.45 | Homo sapiens | - |
- |
- |
2.1.1.45 | Homo sapiens | - |
patients with advanced non-small cell lung cancer | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.1.1.45 | Ma-1 cell | human NSCLC cell line | Homo sapiens | - |
2.1.1.45 | Ma-25 cell | human NSCLC cell line | Homo sapiens | - |
2.1.1.45 | Ma-45 cell | human NSCLC cell line | Homo sapiens | - |
2.1.1.45 | Ma-53 cell | human NSCLC cell line | Homo sapiens | - |
2.1.1.45 | MiaPaCa-2 cell | human NSCLC cell line | Homo sapiens | - |
2.1.1.45 | NCI-H460 cell | human NSCLC cell line | Homo sapiens | - |
2.1.1.45 | non-small cell lung cancer cell line | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.45 | 5,10-methylenetetrahydrofolate + dUMP | - |
Homo sapiens | 7,8-dihydrofolate + dTMP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.45 | TS-DHFR | - |
Homo sapiens |