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Literature summary extracted from

  • Sengupta, S.; Ghosh, S.; Nagaraja, V.
    Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme (2008), Microbiology, 154, 2796-2803.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
5.1.1.3
-
 Mycobacterium tuberculosis

Protein Variants

EC Number Protein Variants Comment Organism
5.1.1.3 C185S decrease in racemization activity, mutant retains its gyrase inhibition ability Mycobacterium tuberculosis
5.1.1.3 C75S decrease in racemization activity, mutant retains its gyrase inhibition ability Mycobacterium tuberculosis
5.1.1.3 C75SC185S less than 10% of wild-type activity, mutant retains its gyrase inhibition ability Mycobacterium tuberculosis
5.1.1.3 additional information overexpression in vivo provides resistance to the action of ciprofloxacin Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.1.3 additional information Mycobacterium tuberculosis enzyme exhibits both racemization activity and DNA gyrase inhibition. The two activities are unlinked and independent of each other. Enzyme-DNA gyrase interaction influences gyrase activity but has no effect on the racemization activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.1.1.3 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.1.3 additional information enzyme exhibits both racemization activity and DNA gyrase inhibition. The two activities are unlinked and independent of each other. Enzyme-DNA gyrase interaction influences gyrase activity but has no effect on the racemization activity Mycobacterium tuberculosis ?
-
 ?