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Literature summary extracted from

  • Duin, E.C.; McKee, M.L.
    A new mechanism for methane production from methyl-coenzyme M reductase as derived from density functional calculations (2008), J. Phys. Chem. B, 112, 2466-2482.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.4.1 CH3-S-CoM + HS-CoB Methanothermobacter marburgensis
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CoM-S-S-CoB + methane
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Organism

EC Number Organism UniProt Comment Textmining
2.8.4.1 Methanothermobacter marburgensis
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-
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.4.1 CH3-S-CoM + HS-CoB
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Methanothermobacter marburgensis CoM-S-S-CoB + methane
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?
2.8.4.1 CH3-S-CoM + HS-CoB catalytic cycle and proton transfer mechanism and energetics, reaction complex formations and mechanism, detailed overview Methanothermobacter marburgensis CoM-S-S-CoB + methane
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2.8.4.1 additional information three general mechanisms for the catalytic production of methane by MCR: (1) the Ni-Me/Ragsdale pathway, (2) the Ni-Me/Thauer pathway, (3) the methyl radical pathway. Density functional calculations and electronic-structure calculations and analysis by computational methods, homolytic Ni-S/Ni-C bonds energies, overview Methanothermobacter marburgensis ?
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?

Synonyms

EC Number Synonyms Comment Organism
2.8.4.1 MCR
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Methanothermobacter marburgensis
2.8.4.1 methyl-coenzyme M reductase
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Methanothermobacter marburgensis

Cofactor

EC Number Cofactor Comment Organism Structure
2.8.4.1 F-430 binding structure, and different oxidation states F430 (Ni(I)/Ni(II)/Ni(III)), Ni(I) is the active state, overview Methanothermobacter marburgensis