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Literature summary extracted from

  • Johnson, W.T.; Anderson, C.M.
    Cardiac cytochrome C oxidase activity and contents of subunits 1 and 4 are altered in offspring by low prenatal copper intake by rat dams (2008), J. Nutr., 138, 1269-1273.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.1.1.9 medicine low prenatal Cu intake by dams is the determinant of CCO activity in cardiac mitochondria of 21-d-old offspring and may lead to the assembly of a less-than-fully active holoenzyme Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 additional information CCO activity, the content of the mitochondrial-encoded CCO subunit 1 (COX1), and the content of the nuclear-encoded subunit COX4 in cardiac mitochondria are reduced in 21-d-old offspring of Cu-deficient dams. COX1 content is normal in 21-d-old cross-fostered offspring of Cu-deficient dams, but CCO activity and COX4 are reduced Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Rattus norvegicus
-
 female Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 heart
-
 Rattus norvegicus
-
7.1.1.9 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 ferrocytochrome c + O2 + H+
-
 Rattus norvegicus ferricytochrome c + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 CCO
-
 Rattus norvegicus
7.1.1.9 CCO subunit 1
-
 Rattus norvegicus
7.1.1.9 COX1
-
 Rattus norvegicus
7.1.1.9 COX4
-
 Rattus norvegicus
7.1.1.9 cytochrome c oxidase
-
 Rattus norvegicus