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Literature summary extracted from

  • Nishi, A.; Kuroiwa, M.; Miller, D.B.; O'Callaghan, J.P.; Bateup, H.S.; Shuto, T.; Sotogaku, N.; Fukuda, T.; Heintz, N.; Greengard, P.; Snyder, G.L.
    Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum (2008), J. Neurosci., 28, 10460-10471.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.53 rolipram PDE4 inhibitor Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.53 additional information Mus musculus PDE4 regulates adenosine A2A receptor signaling in striatopallidal neurons ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.53 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.53 corpus striatum
-
 Mus musculus
-
3.1.4.53 neuron
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.53 3',5'-cAMP + H2O
-
 Mus musculus 5'-AMP
-
 ?
3.1.4.53 additional information PDE4 regulates adenosine A2A receptor signaling in striatopallidal neurons Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.53 PDE4
-
 Mus musculus
3.1.4.53 phosphodiesterase 4
-
 Mus musculus