EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.2.1.1 | acacetin | a flavone, 0.888 mM, pH 6.0, room temperature, 14.1% maximum inhibition | Homo sapiens | |
3.2.1.1 | acarbose | 0.888 mM, pH 6.0, room temperature, 99.2% maximum inhibition | Homo sapiens | |
3.2.1.1 | catechin | a flavonol, 0.888 mM, pH 6.0, room temperature, 13.1% maximum inhibition | Homo sapiens | |
3.2.1.1 | daidzein | a isoflavone, 0.888 mM, pH 6.0, room temperature, 23.3% maximum inhibition | Homo sapiens | |
3.2.1.1 | diosmetin | a flavone, 0.888 mM, pH 6.0, room temperature, 19.2% maximum inhibition | Homo sapiens | |
3.2.1.1 | epicatechin | a flavonol, 0.888 mM, pH 6.0, room temperature, 10.3% maximum inhibition | Homo sapiens | |
3.2.1.1 | eupafolin | a flavone, 0.888 mM, pH 6.0, room temperature, 99.4% maximum inhibition | Homo sapiens | |
3.2.1.1 | fisetin | a flavonol, 0.888 mM, pH 6.0, room temperature, 85.6% maximum inhibition | Homo sapiens | |
3.2.1.1 | genistein | a isoflavone, 0.888 mM, pH 6.0, room temperature, 25.1% maximum inhibition | Homo sapiens | |
3.2.1.1 | genkwanin | a flavone, 0.888 mM, pH 6.0, room temperature, 17.5% maximum inhibition | Homo sapiens | |
3.2.1.1 | hesperetin | a flavanone, 0.888 mM, pH 6.0, room temperature, 39.8% maximum inhibition | Homo sapiens | |
3.2.1.1 | isorhamnetin | a flavonol, 0.888 mM, pH 6.0, room temperature, 35.4% maximum inhibition | Homo sapiens | |
3.2.1.1 | kaempferol | a flavonol, 0.888 mM, pH 6.0, room temperature, 34.5% maximum inhibition | Homo sapiens | |
3.2.1.1 | luteolin | a flavone, 0.888 mM, pH 6.0, room temperature, 88.8% maximum inhibition | Homo sapiens | |
3.2.1.1 | additional information | the inhibitory activity of the flavonoids toward human alpha-amylase depends on the formation of 1. hydrogen bonds between the hydroxyl groups in position R7 and/or R4' of the polyphenol ligands and the catalytic residues of the binding site Asp197 and Glu233 and 2. formation of a conjugated pi-system between either the AC- or B-ring system and Trp59, that stabilizes the interaction with the active site | Homo sapiens | |
3.2.1.1 | myricetin | a flavonol, 0.888 mM, pH 6.0, room temperature, 79% maximum inhibition | Homo sapiens | |
3.2.1.1 | naringenin | a flavanone, 0.888 mM, pH 6.0, room temperature, 26.9% maximum inhibition | Homo sapiens | |
3.2.1.1 | quercetagetin | a flavonol, 0.888 mM, pH 6.0, room temperature, 97.6% maximum inhibition | Homo sapiens | |
3.2.1.1 | quercetin | a flavonol, 0.888 mM, pH 6.0, room temperature, 82.1% maximum inhibition | Homo sapiens | |
3.2.1.1 | Rhamnetin | a flavonol, 0.888 mM, pH 6.0, room temperature, 8.1% maximum inhibition | Homo sapiens | |
3.2.1.1 | scutellarein | a flavone, 0.888 mM, pH 6.0, room temperature, 98.4% maximum inhibition | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.2.1.1 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.2.1.1 | commercial preparation | - |
Homo sapiens | - |
3.2.1.1 | saliva | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.2.1.1 | starch + H2O | potato starch, pH 6.0, room temperature | Homo sapiens | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.2.1.1 | alpha-amylase | type IX-A | Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
3.2.1.1 | additional information | - |
not detectable for kaempferol, isorhamnetin, rhamnetin, genkwarin, diosmetin, acacetin, catechin, epicatechin, hesperetin, naringenin, genistein, and daidzein | Homo sapiens | additional information | |
3.2.1.1 | 0.000996 | - |
pH 6.0, room temperature | Homo sapiens | acarbose | |
3.2.1.1 | 0.00964 | - |
a flavone, pH 6.0, room temperature | Homo sapiens | scutellarein | |
3.2.1.1 | 0.0102 | - |
a flavonol, pH 6.0, room temperature | Homo sapiens | quercetagetin | |
3.2.1.1 | 0.0184 | - |
a flavone, pH 6.0, room temperature | Homo sapiens | luteolin | |
3.2.1.1 | 0.0196 | - |
a flavonol, pH 6.0, room temperature | Homo sapiens | fisetin | |
3.2.1.1 | 0.0214 | - |
a flavonol, pH 6.0, room temperature | Homo sapiens | quercetin | |
3.2.1.1 | 0.0302 | - |
a flavonol, pH 6.0, room temperature | Homo sapiens | myricetin | |
3.2.1.1 | 0.048 | - |
a flavone, pH 6.0, room temperature | Homo sapiens | eupafolin |