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Literature summary extracted from

  • Lo Piparo, E.; Scheib, H.; Frei, N.; Williamson, G.; Grigorov, M.; Chou, C.J.
    Flavonoids for controlling starch digestion: structural requirements for inhibiting human alpha-amylase (2008), J. Med. Chem., 51, 3555-3561.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.1 acacetin a flavone, 0.888 mM, pH 6.0, room temperature, 14.1% maximum inhibition Homo sapiens
3.2.1.1 acarbose 0.888 mM, pH 6.0, room temperature, 99.2% maximum inhibition Homo sapiens
3.2.1.1 catechin a flavonol, 0.888 mM, pH 6.0, room temperature, 13.1% maximum inhibition Homo sapiens
3.2.1.1 daidzein a isoflavone, 0.888 mM, pH 6.0, room temperature, 23.3% maximum inhibition Homo sapiens
3.2.1.1 diosmetin a flavone, 0.888 mM, pH 6.0, room temperature, 19.2% maximum inhibition Homo sapiens
3.2.1.1 epicatechin a flavonol, 0.888 mM, pH 6.0, room temperature, 10.3% maximum inhibition Homo sapiens
3.2.1.1 eupafolin a flavone, 0.888 mM, pH 6.0, room temperature, 99.4% maximum inhibition Homo sapiens
3.2.1.1 fisetin a flavonol, 0.888 mM, pH 6.0, room temperature, 85.6% maximum inhibition Homo sapiens
3.2.1.1 genistein a isoflavone, 0.888 mM, pH 6.0, room temperature, 25.1% maximum inhibition Homo sapiens
3.2.1.1 genkwanin a flavone, 0.888 mM, pH 6.0, room temperature, 17.5% maximum inhibition Homo sapiens
3.2.1.1 hesperetin a flavanone, 0.888 mM, pH 6.0, room temperature, 39.8% maximum inhibition Homo sapiens
3.2.1.1 isorhamnetin a flavonol, 0.888 mM, pH 6.0, room temperature, 35.4% maximum inhibition Homo sapiens
3.2.1.1 kaempferol a flavonol, 0.888 mM, pH 6.0, room temperature, 34.5% maximum inhibition Homo sapiens
3.2.1.1 luteolin a flavone, 0.888 mM, pH 6.0, room temperature, 88.8% maximum inhibition Homo sapiens
3.2.1.1 additional information the inhibitory activity of the flavonoids toward human alpha-amylase depends on the formation of 1. hydrogen bonds between the hydroxyl groups in position R7 and/or R4' of the polyphenol ligands and the catalytic residues of the binding site Asp197 and Glu233 and 2. formation of a conjugated pi-system between either the AC- or B-ring system and Trp59, that stabilizes the interaction with the active site Homo sapiens
3.2.1.1 myricetin a flavonol, 0.888 mM, pH 6.0, room temperature, 79% maximum inhibition Homo sapiens
3.2.1.1 naringenin a flavanone, 0.888 mM, pH 6.0, room temperature, 26.9% maximum inhibition Homo sapiens
3.2.1.1 quercetagetin a flavonol, 0.888 mM, pH 6.0, room temperature, 97.6% maximum inhibition Homo sapiens
3.2.1.1 quercetin a flavonol, 0.888 mM, pH 6.0, room temperature, 82.1% maximum inhibition Homo sapiens
3.2.1.1 Rhamnetin a flavonol, 0.888 mM, pH 6.0, room temperature, 8.1% maximum inhibition Homo sapiens
3.2.1.1 scutellarein a flavone, 0.888 mM, pH 6.0, room temperature, 98.4% maximum inhibition Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.1 commercial preparation
-
Homo sapiens
-
3.2.1.1 saliva
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.1 starch + H2O potato starch, pH 6.0, room temperature Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
3.2.1.1 alpha-amylase type IX-A Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.2.1.1 additional information
-
not detectable for kaempferol, isorhamnetin, rhamnetin, genkwarin, diosmetin, acacetin, catechin, epicatechin, hesperetin, naringenin, genistein, and daidzein Homo sapiens additional information
3.2.1.1 0.000996
-
pH 6.0, room temperature Homo sapiens acarbose
3.2.1.1 0.00964
-
a flavone, pH 6.0, room temperature Homo sapiens scutellarein
3.2.1.1 0.0102
-
a flavonol, pH 6.0, room temperature Homo sapiens quercetagetin
3.2.1.1 0.0184
-
a flavone, pH 6.0, room temperature Homo sapiens luteolin
3.2.1.1 0.0196
-
a flavonol, pH 6.0, room temperature Homo sapiens fisetin
3.2.1.1 0.0214
-
a flavonol, pH 6.0, room temperature Homo sapiens quercetin
3.2.1.1 0.0302
-
a flavonol, pH 6.0, room temperature Homo sapiens myricetin
3.2.1.1 0.048
-
a flavone, pH 6.0, room temperature Homo sapiens eupafolin