EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.47 | 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | Homo sapiens | platelet-activating factor | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | lyso-platelet-activating factor | ? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.149 | Homo sapiens | - |
- |
- |
3.1.1.47 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.3.1.149 | aorta | immunohistochemistry shows PAF-AH expression in the intima and in the media of the aorta | Homo sapiens | - |
2.3.1.149 | artery | detected by immunohistochemistry in the media of mammary arteries | Homo sapiens | - |
3.1.1.47 | aorta | atherogenic aorta | Homo sapiens | - |
3.1.1.47 | artery | nonatherogenic mammary artery | Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
2.3.1.149 | 0.0000008 | - |
transacetylase activity of mammary artery | Homo sapiens |
2.3.1.149 | 0.0000033 | - |
transacetylase activity in aorta | Homo sapiens |
3.1.1.47 | 0.0000001 | - |
acetylhydrolase activity mg tissue, mammary artery, plus Pefablok | Homo sapiens |
3.1.1.47 | 0.0000003 | - |
acetylhydrolase activity mg tissue, aorta, plus Pefablok | Homo sapiens |
3.1.1.47 | 0.0000014 | - |
acetylhydrolase activity mg tissue, mammary artery | Homo sapiens |
3.1.1.47 | 0.0000028 | - |
acetylhydrolase activity mg tissue, aorta | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.149 | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + lyso-phosphatidylcholine | - |
Homo sapiens | ? | - |
? | |
3.1.1.47 | 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O | platelet-activating factor | Homo sapiens | 1-O-alkyl-sn-glycero-3-phosphocholine + acetate | lyso-platelet-activating factor | ? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.149 | PAF-AH | enzyme inactivates PAF bioactivity and possesses both acetylhydrolase and transacetylase activities | Homo sapiens |
3.1.1.47 | PAF-AH | - |
Homo sapiens |
3.1.1.47 | platelet-activating factor acetylhydrolase | - |
Homo sapiens |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.3.1.149 | 37 | - |
assay at | Homo sapiens |
3.1.1.47 | 37 | - |
activity assay | Homo sapiens |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.3.1.149 | 7.4 | - |
assay at | Homo sapiens |
3.1.1.47 | 7.4 | - |
activity assay | Homo sapiens |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.3.1.149 | physiological function | lyso- platelet-activating factor accumulation and an increase in platelet-activating factor bioactivity is observed in the aorta of some patients. In atherogenic aortas, an imbalance between PAF-AH and transacetylase activity, as well as lyso-platelet-activating factor accumulation, may lead to unregulated platelet-activating factor formation and to progression of atherosclerosis | Homo sapiens |