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Literature summary extracted from

  • Tsoukatos, D.C.; Brocheriou, I.; Moussis, V.; Panopoulou, C.P.; Christofidou, E.D.; Koussissis, S.; Sismanidis, S.; Ninio, E.; Siminelakis, S.
    Platelet-activating factor acetylhydrolase and transacetylase activities in human aorta and mammary artery (2008), J. Lipid Res., 49, 2240-2249.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O Homo sapiens platelet-activating factor 1-O-alkyl-sn-glycero-3-phosphocholine + acetate lyso-platelet-activating factor ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.149 Homo sapiens
-
-
-
3.1.1.47 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.149 aorta immunohistochemistry shows PAF-AH expression in the intima and in the media of the aorta Homo sapiens
-
2.3.1.149 artery detected by immunohistochemistry in the media of mammary arteries Homo sapiens
-
3.1.1.47 aorta atherogenic aorta Homo sapiens
-
3.1.1.47 artery nonatherogenic mammary artery Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.149 0.0000008
-
transacetylase activity of mammary artery Homo sapiens
2.3.1.149 0.0000033
-
transacetylase activity in aorta Homo sapiens
3.1.1.47 0.0000001
-
acetylhydrolase activity mg tissue, mammary artery, plus Pefablok Homo sapiens
3.1.1.47 0.0000003
-
acetylhydrolase activity mg tissue, aorta, plus Pefablok Homo sapiens
3.1.1.47 0.0000014
-
acetylhydrolase activity mg tissue, mammary artery Homo sapiens
3.1.1.47 0.0000028
-
acetylhydrolase activity mg tissue, aorta Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.149 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + lyso-phosphatidylcholine
-
Homo sapiens ?
-
?
3.1.1.47 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O platelet-activating factor Homo sapiens 1-O-alkyl-sn-glycero-3-phosphocholine + acetate lyso-platelet-activating factor ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.149 PAF-AH enzyme inactivates PAF bioactivity and possesses both acetylhydrolase and transacetylase activities Homo sapiens
3.1.1.47 PAF-AH
-
Homo sapiens
3.1.1.47 platelet-activating factor acetylhydrolase
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.149 37
-
assay at Homo sapiens
3.1.1.47 37
-
activity assay Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.149 7.4
-
assay at Homo sapiens
3.1.1.47 7.4
-
activity assay Homo sapiens

General Information

EC Number General Information Comment Organism
2.3.1.149 physiological function lyso- platelet-activating factor accumulation and an increase in platelet-activating factor bioactivity is observed in the aorta of some patients. In atherogenic aortas, an imbalance between PAF-AH and transacetylase activity, as well as lyso-platelet-activating factor accumulation, may lead to unregulated platelet-activating factor formation and to progression of atherosclerosis Homo sapiens