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Literature summary extracted from

  • Anand, A.R.; Cucchiarini, M.; Terwilliger, E.F.; Ganju, R.K.
    The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells (2008), J. Immunol., 180, 5636-5644.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 lipopolysaccharide LPS Homo sapiens

Application

EC Number Application Comment Organism
2.7.10.2 medicine Pyk2 may represent a novel target for the development of innovative therapeutic strategies against inflammatory conditions Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.10.2 the kinase-inactive Pyk2 mutant is cloned using an AAV vector Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.10.2 Pyk2K457A Pyk2MT, dominant negative Pyk2 mutant, inactive Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 Pyk2-specific siRNA
-
 Homo sapiens
2.7.10.2 tyrphostin A9
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.10.2 117000
-
 determined by SDS-PAGE and Western Blot analysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine Homo sapiens
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 endothelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + poly(Glu-Tyr) substrate used in the activity assay Homo sapiens ? + ADP
-
 ?
2.7.10.2 ATP + [protein]-L-tyrosine
-
 Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Pyk2
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.10.2 23
-
 immune complex kinase assay Homo sapiens