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Literature summary extracted from

  • Morton, D.B.; Stewart, J.A.; Langlais, K.K.; Clemens-Grisham, R.A.; Vermehren, A.
    Synaptic transmission in neurons that express the Drosophila atypical soluble guanylyl cyclases, Gyc-89Da and Gyc-89Db, is necessary for the successful completion of larval and adult ecdysis (2008), J. Exp. Biol., 211, 1645-1656.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.2 gene encoding isozyme Gyc-89Da, expression analysis and promoter analysis, expression in Saccharomces cerevisiae Drosophila melanogaster
4.6.1.2 gene encoding isozyme Gyc-89Db, expression analysis and promoter analysis, expression in Saccharomces cerevisiae Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
4.6.1.2 additional information generation of an isozyme Gyc-89Da deficient mutant, reduced levels of cGMP in Gyc-89Da neurons have no effect on larval ecdysis or eclosion, but isozyme expression is necessary early in adult development to prevent eclosion, phenotype, overview Drosophila melanogaster
4.6.1.2 additional information generation of an isozyme Gyc-89Db deficient mutant, reduced levels of cGMP in Gyc-89Db neurons have no effect on larval ecdysis or eclosion, but isozyme expression is necessary early in adult development to prevent eclosion, phenotype, overview Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.2 tetanus toxin expression of tetanus toxin in the neurons, that express isozyme Gyc-89Da, blocks their synaptic activity; expression of tetanus toxin in the neurons, that express isozyme Gyc-89Db, blocks their synaptic activity Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 synapse
-
 Drosophila melanogaster 45202
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Drosophila melanogaster isozyme Gyc-89Da in neurons is necessary early in adult development to prevent eclosion, overview 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP Drosophila melanogaster isozyme Gyc-89Db in neurons is necessary early in adult development to prevent eclosion, overview 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Drosophila melanogaster Q9VEU5
-
-
4.6.1.2 Drosophila melanogaster Q9VEU6
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 neuron the isozyme Gyc-89Da is encoded in neurons that are required for larval and adult ecdyses in the fruit fly Drosophila melanogaster
-
4.6.1.2 neuron the isozyme Gyc-89Db is encoded in neurons that are required for larval and adult ecdyses in the fruit fly Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Drosophila melanogaster 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP isozyme Gyc-89Da in neurons is necessary early in adult development to prevent eclosion, overview Drosophila melanogaster 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP isozyme Gyc-89Db in neurons is necessary early in adult development to prevent eclosion, overview Drosophila melanogaster 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 Gyc-89Da
-
 Drosophila melanogaster
4.6.1.2 Gyc-89Db
-
 Drosophila melanogaster
4.6.1.2 soluble guanylyl cyclase
-
 Drosophila melanogaster