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Literature summary extracted from

  • Deghmane, A.E.; Soualhine, H.; Soulhine, H.; Bach, H.; Sendide, K.; Itoh, S.; Tam, A.; Noubir, S.; Talal, A.; Lo, R.; Toyoshima, S.; Av-Gay, Y.; Hmama, Z.
    Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation (2007), J. Cell Sci., 120, 2796-2806.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.8.1.4 medicine direct involvement of LpdC in the prolonged retention of coronin-1 on the phagosome, thus promoting phagosome maturation arrest. Under the influence of IFNgamma, LRG-47 is recruited to the phagosome and mediates dislocation of coronin-1 leading ultimately to phagosome acidification and recruitment of lysosomal vacuoles and phagolyosome fusion Mycobacterium tuberculosis
1.8.1.4 medicine direct involvement of LpdC in the prolonged retention of coronin-1 on the phagosome, thus promoting phagosome maturation arrest. Under the influence of IFNgamma, LRG-47 is recruited to the phagosome and mediates dislocation of coronin-1 leading ultimately to phagosome acidification and recruitment of lysosomal vacuoles and phagolyosome fusion Mycobacterium tuberculosis variant bovis BCG

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.8.1.4 Mycobacterium smegmatis over-expressing LpdC protein Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.4 additional information expression of LRG-47, as well as IFNgamma stimulation, block intracellular interaction of coronin-1 with LpdC Mycobacterium tuberculosis
1.8.1.4 additional information expression of LRG-47, as well as IFNgamma stimulation, block intracellular interaction of coronin-1 with LpdC Mycobacterium tuberculosis variant bovis BCG

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.1.4 50000
-
 x * 50000, SDS-PAGE Mycobacterium tuberculosis
1.8.1.4 50000
-
 ? * 50000, SDS-PAGE Mycobacterium tuberculosis variant bovis BCG

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.4 Mycobacterium tuberculosis
-
-
-
1.8.1.4 Mycobacterium tuberculosis variant bovis BCG
-
-
-
1.8.1.4 no activity in Mycobacterium smegmatis
-
-
-

Subunits

EC Number Subunits Comment Organism
1.8.1.4 ? x * 50000, SDS-PAGE Mycobacterium tuberculosis
1.8.1.4 ? ? * 50000, SDS-PAGE Mycobacterium tuberculosis variant bovis BCG

Synonyms

EC Number Synonyms Comment Organism
1.8.1.4 CIP50
-
 Mycobacterium tuberculosis
1.8.1.4 CIP50
-
 Mycobacterium tuberculosis variant bovis BCG
1.8.1.4 coronin-interacting protein
-
 Mycobacterium tuberculosis
1.8.1.4 coronin-interacting protein
-
 Mycobacterium tuberculosis variant bovis BCG
1.8.1.4 E3
-
 Mycobacterium tuberculosis
1.8.1.4 lipoamide dehydrogenase C
-
 Mycobacterium tuberculosis
1.8.1.4 lipoamide dehydrogenase C
-
 Mycobacterium tuberculosis variant bovis BCG
1.8.1.4 LpdC
-
 Mycobacterium tuberculosis
1.8.1.4 LpdC
-
 Mycobacterium tuberculosis variant bovis BCG

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.8.1.4 Mycobacterium tuberculosis
-
-
 5.4
1.8.1.4 Mycobacterium tuberculosis variant bovis BCG
-
-
 5.4