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Literature summary extracted from

  • Dang, H.; Liu, Y.; Pang, W.; Wang, N.; Shyy, J.Y.; Zhu, Y.
    Suppression of 2,3-oxidosqualene cyclase by high-fat diet contributes to liver X receptor-alpha -mediated improvement of hepatic lipid profile (2009), J. Biol. Chem., 284, 6218-6226.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.7 cholesterol an increased cholesterol level suppresses the expression of 2,3-oxidosqualene cyclase Mus musculus
5.4.99.7 cholesterol an increased cholesterol level suppresses the expression of 2,3-oxidosqualene cyclase Rattus norvegicus
5.4.99.7 additional information a high fat diet reduces OSC expression in the liver Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.4.99.7 microsome
-
 Mus musculus
-
-
5.4.99.7 microsome
-
 Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.7 Mus musculus
-
-
-
5.4.99.7 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.4.99.7 hepatocyte
-
 Rattus norvegicus
-
5.4.99.7 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.7 (S)-2,3-oxidosqualene
-
 Mus musculus lanosterol
-
 ?
5.4.99.7 (S)-2,3-oxidosqualene
-
 Rattus norvegicus lanosterol
-
 ?
5.4.99.7 2,3:22,23-diepoxysqualene
-
 Mus musculus 24(S),25-epoxylanosterol
-
 ?
5.4.99.7 2,3:22,23-diepoxysqualene
-
 Rattus norvegicus 24(S),25-epoxylanosterol
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.7 2,3-Oxidosqualene cyclase
-
 Mus musculus
5.4.99.7 2,3-Oxidosqualene cyclase
-
 Rattus norvegicus
5.4.99.7 OSC
-
 Mus musculus
5.4.99.7 OSC
-
 Rattus norvegicus