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Literature summary extracted from

  • Boshoff, H.I.; Xu, X.; Tahlan, K.; Dowd, C.S.; Pethe, K.; Camacho, L.R.; Park, T.H.; Yun, C.S.; Schnappinger, D.; Ehrt, S.; Williams, K.J.; Barry, C.E.
    Biosynthesis and recycling of nicotinamide cofactors in Mycobacterium tuberculosis. An essential role for NAD in nonreplicating bacilli (2008), J. Biol. Chem., 283, 19329-19341.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.5.1 3-[([7-[5-(benzyloxy)-2-(methoxycarbonyl)-1H-indol-1-yl]heptyl]oxy)carbonyl]-1-methylpyridinium
-
Mycobacterium tuberculosis
6.3.5.1 4-[([7-[5-(benzyloxy)-2-(methoxycarbonyl)-1H-indol-1-yl]heptyl]oxy)carbonyl]-N,N,N-trimethylanilinium
-
Mycobacterium tuberculosis
6.3.5.1 4-[([8-[5-(benzyloxy)-1H-indol-1-yl]octyl]oxy)carbonyl]-N,N,N-trimethylanilinium
-
Mycobacterium tuberculosis
6.3.5.1 4-[2-([9-[5-(benzyloxy)-2-(methoxycarbonyl)-1H-indol-1-yl]nonyl]oxy)-2-oxoethyl]-N,N,N-trimethylanilinium
-
Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
6.3.5.1 Mycobacterium tuberculosis
-
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.3.5.1 0.0218
-
pH 8.5, 37°C Mycobacterium tuberculosis 4-[([7-[5-(benzyloxy)-2-(methoxycarbonyl)-1H-indol-1-yl]heptyl]oxy)carbonyl]-N,N,N-trimethylanilinium
6.3.5.1 0.0248
-
pH 8.5, 37°C Mycobacterium tuberculosis 4-[([8-[5-(benzyloxy)-1H-indol-1-yl]octyl]oxy)carbonyl]-N,N,N-trimethylanilinium
6.3.5.1 0.0578
-
pH 8.5, 37°C Mycobacterium tuberculosis 4-[2-([9-[5-(benzyloxy)-2-(methoxycarbonyl)-1H-indol-1-yl]nonyl]oxy)-2-oxoethyl]-N,N,N-trimethylanilinium
6.3.5.1 0.0633
-
pH 8.5, 37°C Mycobacterium tuberculosis 3-[([7-[5-(benzyloxy)-2-(methoxycarbonyl)-1H-indol-1-yl]heptyl]oxy)carbonyl]-1-methylpyridinium