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Literature summary extracted from

  • Chan, A.L.; Huang, H.L.; Chien, H.C.; Chen, C.M.; Lin, C.N.; Ko, W.C.
    Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [3H]-rolipram binding in guinea pig tissues (2008), Invest. New Drugs, 26, 417-424.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone Ro20-1724 Cavia porcellus
3.1.4.17 cGMP
-
 Cavia porcellus
3.1.4.17 Milrinone
-
 Cavia porcellus
3.1.4.17 quercetin
-
 Cavia porcellus
3.1.4.17 quercetin-3,5,7,3',4'-O-pentaacetate
-
 Cavia porcellus
3.1.4.17 quercetin-3,5,7,3',4'-O-pentamethylether
-
 Cavia porcellus
3.1.4.17 quercetin-3,7,3',4'-O-tetramethylether
-
 Cavia porcellus
3.1.4.17 quercetin-3,7,4'-O-trimethylether ayanin Cavia porcellus
3.1.4.17 quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate
-
 Cavia porcellus
3.1.4.17 quercetin-3-O-methylether
-
 Cavia porcellus
3.1.4.17 rolipram
-
 Cavia porcellus
3.1.4.35 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone Ro20-1724 Cavia porcellus
3.1.4.35 additional information not inhibited by quercetin, quercetin-3,7,3',4'-O-tetramethylether, quercetin-3,5,7,3',4'-O-pentaacetate, and quercetin-3,7,4'-O-trimethylether Cavia porcellus
3.1.4.35 quercetin-3,5,7,3',4'-O-pentamethylether
-
 Cavia porcellus
3.1.4.35 quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate
-
 Cavia porcellus
3.1.4.35 quercetin-3-O-methylether
-
 Cavia porcellus
3.1.4.35 rolipram
-
 Cavia porcellus
3.1.4.35 zaprinast
-
 Cavia porcellus
3.1.4.53 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone Ro20-1724 Cavia porcellus
3.1.4.53 additional information not inhibited by quercetin-3,7,3',4'-O-tetramethylether Cavia porcellus
3.1.4.53 quercetin
-
 Cavia porcellus
3.1.4.53 quercetin-3,5,7,3',4'-O-pentaacetate
-
 Cavia porcellus
3.1.4.53 quercetin-3,5,7,3',4'-O-pentamethylether
-
 Cavia porcellus
3.1.4.53 quercetin-3,7,4'-O-trimethylether ayanin Cavia porcellus
3.1.4.53 quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate
-
 Cavia porcellus
3.1.4.53 quercetin-3-O-methylether
-
 Cavia porcellus
3.1.4.53 rolipram
-
 Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Cavia porcellus
-
-
-
3.1.4.35 Cavia porcellus
-
-
-
3.1.4.53 Cavia porcellus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.17 partially purified by Q-Sepharose column chromatography Cavia porcellus
3.1.4.35 partially purified by Q-Sepharose column chromatography Cavia porcellus
3.1.4.53 partially purified by Q-Sepharose column chromatography Cavia porcellus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.17 heart
-
 Cavia porcellus
-
3.1.4.35 lung
-
 Cavia porcellus
-
3.1.4.53 lung
-
 Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 nucleoside 3',5'-cyclic phosphate + H2O
-
 Cavia porcellus nucleoside 5'-phosphate
-
 ?
3.1.4.35 3',5'-cGMP + H2O
-
 Cavia porcellus 5'-GMP
-
 ?
3.1.4.53 3',5'-cAMP + H2O
-
 Cavia porcellus 5'-AMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 PDE3
-
 Cavia porcellus
3.1.4.17 phosphodiesterase-3
-
 Cavia porcellus
3.1.4.35 PDE5 cGMP-specific enzyme Cavia porcellus
3.1.4.35 phosphodiesterase-5
-
 Cavia porcellus
3.1.4.53 PDE4 cAMP-specific enzyme Cavia porcellus
3.1.4.53 phosphodiesterase-4
-
 Cavia porcellus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.17 0.0008
-
 PDE3 Cavia porcellus quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate
3.1.4.17 0.0016
-
 PDE3 Cavia porcellus quercetin-3-O-methylether
3.1.4.17 0.002
-
 PDE3 Cavia porcellus Milrinone
3.1.4.17 0.002
-
 PDE3 Cavia porcellus quercetin-3,5,7,3',4'-O-pentaacetate
3.1.4.17 0.0041
-
 PDE3 Cavia porcellus quercetin-3,7,4'-O-trimethylether
3.1.4.17 0.0047
-
 PDE3 Cavia porcellus quercetin-3,5,7,3',4'-O-pentamethylether
3.1.4.17 0.0056
-
 PDE3 Cavia porcellus quercetin
3.1.4.17 0.0228
-
 PDE3 Cavia porcellus quercetin-3,7,3',4'-O-tetramethylether
3.1.4.17 0.0869
-
 PDE3 Cavia porcellus quercetin-3-O-methylether
3.1.4.35 0.0023
-
 PDE5 Cavia porcellus zaprinast
3.1.4.35 0.0111
-
 PDE5 Cavia porcellus quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate
3.1.4.35 0.0137
-
 PDE5 Cavia porcellus quercetin-3,5,7,3',4'-O-pentamethylether
3.1.4.35 0.0869
-
 PDE5 Cavia porcellus quercetin-3-O-methylether
3.1.4.53 0.0023
-
 PDE4 Cavia porcellus rolipram
3.1.4.53 0.0039
-
 PDE4 Cavia porcellus quercetin-3-O-methyl-5,7,3',4'-O-tetraacetate
3.1.4.53 0.0051
-
 PDE4 Cavia porcellus quercetin-3,5,7,3',4'-O-pentamethylether
3.1.4.53 0.0087
-
 PDE4 Cavia porcellus 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
3.1.4.53 0.0099
-
 PDE4 Cavia porcellus quercetin
3.1.4.53 0.0158
-
 PDE4 Cavia porcellus quercetin-3,7,4'-O-trimethylether
3.1.4.53 0.0185
-
 PDE4 Cavia porcellus quercetin-3,5,7,3',4'-O-pentaacetate
3.1.4.53 0.0285
-
 PDE4 Cavia porcellus quercetin-3-O-methylether