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Literature summary extracted from

  • Fujimoto, K.; Matsumura, Y.; Tani, Y.; Ozono, S.; Hirao, Y.; Okajima, E.
    Tissue levels of pyrimidine nucleoside phosphorylase activity in human and rodent bladder cancer and normal bladder tissue (2007), Int. J. Urol., 14, 754-759.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.3 pyrimidine nucleoside + phosphate Rattus norvegicus most pyrimidine nucleosides except for 4-amino-substituted species like deoxycytidine pyrimidine base + alpha-D-ribose 1-phosphate or alpha-D-deoxyribose 1-phosphate r

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.3 Mus musculus
-
 C3H/He female mice
-
2.4.2.3 Rattus norvegicus
-
 Fischer 344 male rats
-
2.4.2.4 Homo sapiens P19971
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.2.3 bladder N-butyl-N-(4-hydoxybutyl) nitrosamine (BBN) treatment for 12 weeks induces invasive cancer development in mice Mus musculus
-
2.4.2.3 bladder N-butyl-N-(4-hydoxybutyl) nitrosamine (BBN) treatment for 12 weeks induces superficial cancer development in rats Rattus norvegicus
-
2.4.2.3 bladder transitional cell carcinoma cell 12 weeks after initiation of BBN treatment: higher PyNpase level in superficial cancer and hyperplasia compared to controls, 16 and 20 weeks after initiation of BBN treatment: higher PyNpase level in superficial cancer but not in hyperplasia compared to controls Rattus norvegicus
-
2.4.2.3 bladder transitional cell carcinoma cell 12, 16 and 20 weeks after initiation of BBN treatment: higher PyNpase level in invasive carcinoma and hyperplasia compared to controls Mus musculus
-
2.4.2.4 bladder higher PyNpase levels in normal tissue adjacent to tumor, AN, than in normal tissue, N Homo sapiens
-
2.4.2.4 bladder transitional cell carcinoma cell higher PyNpase levels in tumor tissue than in normal tissue or tissue adjacent to the tumor, PyNpase levels independent of age, gender, history of recurrence, multiplicity, tumor size, tumor shape, pathological stage (Ta, T1-4), PyNpase levels differ between histological stages being highest in G3, and between papillary versus non-papillary growth pattern, higher PyPnase levels in high-risk group (G3 or Tis or T2) than in low-risk group (primary, single, G1 and Ta) Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.3 pyrimidine nucleoside + phosphate most pyrimidine nucleosides except for 4-amino-substituted species like deoxycytidine Rattus norvegicus pyrimidine base + alpha-D-ribose 1-phosphate or alpha-D-deoxyribose 1-phosphate r
2.4.2.3 uridine + phosphate
-
 Mus musculus uracil + alpha-D-ribose 1-phosphate
-
 r
2.4.2.3 uridine + phosphate
-
 Rattus norvegicus uracil + alpha-D-ribose 1-phosphate
-
 r
2.4.2.4 thymidine + phosphate
-
 Homo sapiens thymine + alpha-D-deoxyribose 1-phosphate
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.4.2.3 pynpase
-
 Mus musculus
2.4.2.3 pynpase
-
 Rattus norvegicus
2.4.2.3 pyrimidine nucleoside phosphorylase
-
 Mus musculus
2.4.2.3 pyrimidine nucleoside phosphorylase
-
 Rattus norvegicus
2.4.2.3 uridine phosphorylase
-
 Mus musculus
2.4.2.3 uridine phosphorylase
-
 Rattus norvegicus
2.4.2.4 pynpase
-
 Homo sapiens
2.4.2.4 pyrimidine nucleoside phosphorylase
-
 Homo sapiens
2.4.2.4 thymidine phosphorylase
-
 Homo sapiens