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Literature summary extracted from

  • Badawy, A.A.; Morgan, C.J.
    Tryptophan metabolites as potent inhibitors of aldehyde dehydrogenase activity and potential alcoholism-aversion therapeutic agents (2007), Int. Congr. Ser., 1304, 344-351.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.3 3-hydroxyanthranilic acid 46% inhibition at 0.002 mM Rattus norvegicus
1.2.1.3 3-hydroxykynurenine 55% inhibition at 0.002 mM Rattus norvegicus
1.2.1.3 5-hydroxytryptophan 23% inhibition at 0.1 mM Saccharomyces cerevisiae
1.2.1.3 Disulfiram 42% inhibition at 0.002 mM Rattus norvegicus
1.2.1.3 Disulfiram 72% inhibition at 0.002 mM Saccharomyces cerevisiae
1.2.1.3 harman 18% inhibition at 0.1 mM Saccharomyces cerevisiae
1.2.1.3 indol-3-ylpyruvic acid 30% inhibition at 0.002 mM Rattus norvegicus
1.2.1.3 indol-3-ylpyruvic acid 55% inhibition at 0.002 mM Saccharomyces cerevisiae
1.2.1.3 Kynurenic acid 40% inhibition at 0.002 mM Rattus norvegicus
1.2.1.3 kynurenine 24% inhibition at 0.1 mM Saccharomyces cerevisiae
1.2.1.3 norharman 23% inhibition at 0.1 mM Saccharomyces cerevisiae
1.2.1.3 xanthurenic acid 56% inhibition at 0.1 mM Saccharomyces cerevisiae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.3 mitochondrion
-
 Rattus norvegicus 5739
-
1.2.1.3 mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.3 Rattus norvegicus
-
-
-
1.2.1.3 Saccharomyces cerevisiae
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.3 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.3 acetaldehyde + NAD+ + H2O
-
 Rattus norvegicus acetate + NADH + H+
-
 ?
1.2.1.3 acetaldehyde + NAD+ + H2O
-
 Saccharomyces cerevisiae acetate + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.3 ALDH
-
 Rattus norvegicus
1.2.1.3 ALDH
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.3 NAD+
-
 Rattus norvegicus
1.2.1.3 NAD+
-
 Saccharomyces cerevisiae