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Literature summary extracted from

  • Archambault, V.; Davino, P.P.; Deery, M.J.; Lilley, K.S.; Glover, D.M.
    Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis (2008), Genes Dev., 22, 2707-2720.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.21 into the pDONR221lambda entry vector, the gene is recombined in different destination vectors for expression in fusion with GFP or protein A Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.21 L408A mutant for interaction studies with Map205 Drosophila melanogaster
2.7.11.21 V396A mutant for interaction studies with Map205 Drosophila melanogaster
2.7.11.21 W395F mutant for interaction studies with Map205 Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.11.21 Map205 Map205 can stabilize Polo and inhibit its cellular activity in vivo Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.21 centromere
-
Drosophila melanogaster
-
-
2.7.11.21 centrosome
-
Drosophila melanogaster 5813
-
2.7.11.21 chromosome
-
Drosophila melanogaster 5694
-
2.7.11.21 microtubule
-
Drosophila melanogaster 5874
-
2.7.11.21 spindle
-
Drosophila melanogaster 5819
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.21 ATP + protein Drosophila melanogaster
-
ADP + phosphoprotein
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.21 Drosophila melanogaster
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.11.21 protein A-affinity purification is performed Drosophila melanogaster

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.21 embryo
-
Drosophila melanogaster
-
2.7.11.21 larva
-
Drosophila melanogaster
-
2.7.11.21 neuroblast
-
Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.21 ATP + protein
-
Drosophila melanogaster ADP + phosphoprotein
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.21 PLK
-
Drosophila melanogaster
2.7.11.21 Polo kinase
-
Drosophila melanogaster
2.7.11.21 polo-like kinase
-
Drosophila melanogaster