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Literature summary extracted from

  • Usha, V.; Dover, L.G.; Roper, D.L.; Besra, G.S.
    Characterization of Mycobacterium tuberculosis diaminopimelic acid epimerase: paired cysteine residues are crucial for racemization (2008), FEMS Microbiol. Lett., 280, 57-63.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
5.1.1.7 C226A complete loss of activity Mycobacterium tuberculosis
5.1.1.7 C226S severely compromised catalytic efficiency Mycobacterium tuberculosis
5.1.1.7 C87A complete loss of activity Mycobacterium tuberculosis
5.1.1.7 C87S severely compromised catalytic efficiency despite decrease in Km value Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.1.1.7 1,2-benzisothiazolidine 3-one 30 nM, complete inhibition Mycobacterium tuberculosis
5.1.1.7 2-nitro-5-thiocyanatobenzoate 30 nM, complete inhibition Mycobacterium tuberculosis
5.1.1.7 5,5'-dithiobis(2-nitrobenzoic acid) 30 nM, complete inhibition Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
5.1.1.7 0.07
-
meso-diaminoheptanedioate mutant C87S, pH 7.5, 30°C Mycobacterium tuberculosis
5.1.1.7 0.166
-
meso-diaminoheptanedioate wild-type, pH 7.5, 30°C Mycobacterium tuberculosis
5.1.1.7 0.215
-
meso-diaminoheptanedioate mutant C226S, pH 7.5, 30°C Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
5.1.1.7 Mycobacterium tuberculosis P9WP19
-
-
5.1.1.7 Mycobacterium tuberculosis H37Rv P9WP19
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.1.1.7 meso-diaminoheptanedioate
-
Mycobacterium tuberculosis LL-2,6-diaminoheptanedioate
-
r
5.1.1.7 meso-diaminoheptanedioate
-
Mycobacterium tuberculosis H37Rv LL-2,6-diaminoheptanedioate
-
r

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.1.1.7 0.001
-
meso-diaminoheptanedioate mutant C87S, pH 7.5, 30°C Mycobacterium tuberculosis
5.1.1.7 0.0025
-
meso-diaminoheptanedioate mutant C226S, pH 7.5, 30°C Mycobacterium tuberculosis
5.1.1.7 0.1465
-
meso-diaminoheptanedioate wild-type, pH 7.5, 30°C Mycobacterium tuberculosis