EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
5.1.1.7 | C226A | complete loss of activity | Mycobacterium tuberculosis |
5.1.1.7 | C226S | severely compromised catalytic efficiency | Mycobacterium tuberculosis |
5.1.1.7 | C87A | complete loss of activity | Mycobacterium tuberculosis |
5.1.1.7 | C87S | severely compromised catalytic efficiency despite decrease in Km value | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
5.1.1.7 | 1,2-benzisothiazolidine 3-one | 30 nM, complete inhibition | Mycobacterium tuberculosis | |
5.1.1.7 | 2-nitro-5-thiocyanatobenzoate | 30 nM, complete inhibition | Mycobacterium tuberculosis | |
5.1.1.7 | 5,5'-dithiobis(2-nitrobenzoic acid) | 30 nM, complete inhibition | Mycobacterium tuberculosis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.1.1.7 | 0.07 | - |
meso-diaminoheptanedioate | mutant C87S, pH 7.5, 30°C | Mycobacterium tuberculosis | |
5.1.1.7 | 0.166 | - |
meso-diaminoheptanedioate | wild-type, pH 7.5, 30°C | Mycobacterium tuberculosis | |
5.1.1.7 | 0.215 | - |
meso-diaminoheptanedioate | mutant C226S, pH 7.5, 30°C | Mycobacterium tuberculosis |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
5.1.1.7 | Mycobacterium tuberculosis | P9WP19 | - |
- |
5.1.1.7 | Mycobacterium tuberculosis H37Rv | P9WP19 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
5.1.1.7 | meso-diaminoheptanedioate | - |
Mycobacterium tuberculosis | LL-2,6-diaminoheptanedioate | - |
r | |
5.1.1.7 | meso-diaminoheptanedioate | - |
Mycobacterium tuberculosis H37Rv | LL-2,6-diaminoheptanedioate | - |
r |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
5.1.1.7 | 0.001 | - |
meso-diaminoheptanedioate | mutant C87S, pH 7.5, 30°C | Mycobacterium tuberculosis | |
5.1.1.7 | 0.0025 | - |
meso-diaminoheptanedioate | mutant C226S, pH 7.5, 30°C | Mycobacterium tuberculosis | |
5.1.1.7 | 0.1465 | - |
meso-diaminoheptanedioate | wild-type, pH 7.5, 30°C | Mycobacterium tuberculosis |