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Literature summary extracted from

  • Smith, E.L.; Schuchman, E.H.
    The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases (2008), FASEB J., 22, 3419-3431.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.4.12 medicine ASM plays a complex and varied role in brain development, as well as in the pathogenesis of several common neurological diseases, ASM is particularly intriguing as an antioncogenic drug, ASM is associated with the type A Niemann-Pick disease, atherosclerosis, Wilson disease, hepatic autoimmune disease, alcohol-induced liver disease, cerebral ischemia, emphysema, cystic fibrosis, and cancer Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.12 expressed in CHO cells and in Mus musculus Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 D609 nonspecific sphingomyelinase inhibitor Homo sapiens
3.1.4.12 additional information desipramine is a cationic amphiphile that triggers ASM proteolysis Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 lysosome
-
 Homo sapiens 5764
-
3.1.4.12 membrane phosphorylation of a specific serine residue on ASM (S508) by protein kinase C-delta is required for its translocation to the cell surface Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.12 72000
-
 estimated molecular weight, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Homo sapiens ASM is necessary for stress-induced cell death ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.4.12 glycoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 blood
-
 Homo sapiens
-
3.1.4.12 blood plasma a secreted, zinc-activated form of ASM is found in the plasma which plays an important role in the development of atherosclerosis Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information ASM is necessary for stress-induced cell death Homo sapiens ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
 Homo sapiens
3.1.4.12 ASM
-
 Homo sapiens