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Literature summary extracted from

  • da Silva, S.L.; Calgarotto, A.K.; Maso, V.; Damico, D.C.; Baldasso, P.; Veber, C.L.; Villar, J.A.; Oliveira, A.R.; Comar, M.; Oliveira, K.M.; Marangoni, S.
    Molecular modeling and inhibition of phospholipase A2 by polyhydroxy phenolic compounds (2009), Eur. J. Med. Chem., 44, 312-321.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 1,3,5-trihydroxybenzene potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview Crotalus adamanteus
3.1.1.4 1,3-dihydroxy benzene potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview Crotalus adamanteus
3.1.1.4 2,4,6-trihydroxy acetophenone potent inhibition of enzymatic activity and endemic activity of PLA2, binding structure, overview Crotalus adamanteus
3.1.1.4 2,4-dihydroxy acetophenone binding structure, overview Crotalus adamanteus
3.1.1.4 2,6-dihydroxy acetophenone binding structure, overview Crotalus adamanteus
3.1.1.4 additional information molecular modeling of the inhibition mechanism of polyhydroxylated phenols Crotalus adamanteus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.4 extracellular
-
 Crotalus adamanteus
-
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Crotalus adamanteus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.1.4 native enzyme by gel filtration and C18 reverse phase HPLC Crotalus adamanteus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 venom
-
 Crotalus adamanteus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 1-hexadecanoyl-2-(1-pyrenedecanoyl)-sn-glycero-3-phosphoglycerol + H2O micellar substrate Crotalus adamanteus ?
-
 ?
3.1.1.4 additional information the enzyme causes endema when applicated to the right footpad of male Swiss mice Crotalus adamanteus ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.1.1.4 37
-
 assay at Crotalus adamanteus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.1.4 8
-
 assay at Crotalus adamanteus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.4 0.00000872
-
 1,3-dihydroxy benzene pH 8.0, 37°C Crotalus adamanteus
3.1.1.4 0.00000874
-
 2,4,6-trihydroxy acetophenone pH 8.0, 37°C Crotalus adamanteus
3.1.1.4 0.00000877
-
 1,3,5-trihydroxybenzene pH 8.0, 37°C Crotalus adamanteus
3.1.1.4 0.00003
-
 2,6-dihydroxy acetophenone pH 8.0, 37°C Crotalus adamanteus
3.1.1.4 0.000032
-
 2,4-dihydroxy acetophenone pH 8.0, 37°C Crotalus adamanteus