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Literature summary extracted from

  • Tayama, Y.; Moriyasu, A.; Sugihara, K.; Ohta, S.; Kitamura, S.
    Developmental changes of aldehyde oxidase in postnatal rat liver (2007), Drug Metab. Pharmacokinet., 22, 119-124.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.2.3.1 medicine aldehyde oxidase activity in rats estimated on the basis of benzaldehyde, N1-methylnicotinamide and methotrexate oxidase activities rapidly increases from birth, reaching a plateau within 4 weeks, and is regulated by expression of the protein. Aldehyde oxidase plays an important role in metabolizing many drugs that may be administered to pediatric patients. Developmental changes are important for the clinical application in infants of methotrexate and other drugs that are detoxified by aldehyde oxidase Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.3.1 cytosol
-
 Rattus norvegicus 5829
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Organism

EC Number Organism UniProt Comment Textmining
1.2.3.1 Rattus norvegicus
-
 Sea:SD rats
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.3.1 liver postnatal day 1, 7 and 14 rats show little or no liver aldehyde oxidase activity. Activity is markedly increased in liver cytosol from rats after postnatal day 14 and is then maintained up to 6 weeks Rattus norvegicus
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.3.1 benzaldehyde + H2O + O2
-
 Rattus norvegicus benzoate + H2O2
-
 ?
1.2.3.1 methotrexate + H2O + O2
-
 Rattus norvegicus 7-hydroxymethotrexate + H2O2
-
 ?
1.2.3.1 N1-methylnicotinamide + H2O + O2
-
 Rattus norvegicus N1-methyl-2-pyridone-5-carboxamide + N1-methyl-4-pyridone-3-carboxamide + H2O2
-
 ?