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Literature summary extracted from

  • Bandele, O.J.; Clawson, S.J.; Osheroff, N.
    Dietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancement (2008), Chem. Res. Toxicol., 21, 1253-1260.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.2.2 (-)-epigallocatechin redox-dependent topoisomerase II poison Homo sapiens
5.6.2.2 (-)-epigallocatechin gallate redox-dependent topoisomerase II poison Homo sapiens
5.6.2.2 kaempferol
-
 Homo sapiens
5.6.2.2 additional information not inhibited by (-)-epicatechin gallate and (-)-epicatechin Homo sapiens
5.6.2.2 myricetin
-
 Homo sapiens
5.6.2.2 quercetin
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
5.6.2.2 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.2.2 supercoiled DNA + ATP + H2O
-
 Homo sapiens catenated DNA networks + ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.2.2 topoisomerase IIalpha
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
5.6.2.2 ATP
-
 Homo sapiens