EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
6.3.2.6 | Mg2+ | - |
Escherichia coli | |
6.3.2.6 | Mg2+ | - |
Homo sapiens | |
6.3.2.6 | Mg2+ | - |
Thermotoga maritima | |
6.3.2.6 | Mg2+ | - |
Saccharomyces cerevisiae |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | Homo sapiens | PurCE performs the sixth and seventh of ten steps in the purine biosynthesis, pathway overview | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | Escherichia coli | seventh of ten steps in the purine biosynthesis, ligation of the carboxylate group of CAIR to the amino group of aspartate, pathway overview | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | Thermotoga maritima | seventh of ten steps in the purine biosynthesis, pathway overview | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | Saccharomyces cerevisiae | seventh of ten steps in the purine biosynthesis, pathway overview | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.2.6 | Escherichia coli | - |
gene purC | - |
6.3.2.6 | Homo sapiens | - |
gene purCE | - |
6.3.2.6 | Saccharomyces cerevisiae | P27616 | gene purC | - |
6.3.2.6 | Thermotoga maritima | - |
gene purC | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | - |
Homo sapiens | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | i.e. N-succinocarboxamide-5-aminoimidazole ribonucleotide or SAICAR | ? | |
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | - |
Thermotoga maritima | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | i.e. N-succinocarboxamide-5-aminoimidazole ribonucleotide or SAICAR | ? | |
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | - |
Saccharomyces cerevisiae | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | i.e. N-succinocarboxamide-5-aminoimidazole ribonucleotide or SAICAR | ? | |
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | PurCE performs the sixth and seventh of ten steps in the purine biosynthesis, pathway overview | Homo sapiens | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | seventh of ten steps in the purine biosynthesis, ligation of the carboxylate group of CAIR to the amino group of aspartate, pathway overview | Escherichia coli | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | seventh of ten steps in the purine biosynthesis, pathway overview | Thermotoga maritima | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | seventh of ten steps in the purine biosynthesis, pathway overview | Saccharomyces cerevisiae | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
? | |
6.3.2.6 | ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate | ligation of the carboxylate group of CAIR to the amino group of aspartate | Escherichia coli | ADP + phosphate + (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | i.e. N-succinocarboxamide-5-aminoimidazole ribonucleotide or SAICAR | ? | |
6.3.2.6 | additional information | in higher organisms PurC and PurE are fused to form a bifunctional enzyme, overview, active site structure, overview | Homo sapiens | ? | - |
? | |
6.3.2.6 | additional information | in lower organisms PurC and PurE are not fused as in higher organisms, active site structure, overview | Escherichia coli | ? | - |
? | |
6.3.2.6 | additional information | in lower organisms PurC and PurE are not fused as in higher organisms, active site structure, overview | Thermotoga maritima | ? | - |
? | |
6.3.2.6 | additional information | in lower organisms PurC and PurE are not fused as in higher organisms, active site structure, overview | Saccharomyces cerevisiae | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
6.3.2.6 | dimer | structure overview | Thermotoga maritima |
6.3.2.6 | dimer | structure overview, PDB ID 2GQS | Escherichia coli |
6.3.2.6 | monomer | structure overview | Saccharomyces cerevisiae |
6.3.2.6 | octamer | 4 dimers of PurC around a core of octameric PurE, the PurC dimers do not contact each other, structure overview, PDB ID 2H31 | Homo sapiens |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.3.2.6 | More | the enzyme is a member of the ATP-grasp superfamily | Escherichia coli |
6.3.2.6 | More | the enzyme is a member of the ATP-grasp superfamily | Homo sapiens |
6.3.2.6 | More | the enzyme is a member of the ATP-grasp superfamily | Thermotoga maritima |
6.3.2.6 | More | the enzyme is a member of the ATP-grasp superfamily | Saccharomyces cerevisiae |
6.3.2.6 | PurC | - |
Escherichia coli |
6.3.2.6 | PurC | - |
Thermotoga maritima |
6.3.2.6 | PurC | - |
Saccharomyces cerevisiae |
6.3.2.6 | PurCE | - |
Homo sapiens |
6.3.2.6 | SAICAR synthase | - |
Escherichia coli |
6.3.2.6 | SAICAR synthase | - |
Homo sapiens |
6.3.2.6 | SAICAR synthase | - |
Thermotoga maritima |
6.3.2.6 | SAICAR synthase | - |
Saccharomyces cerevisiae |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.3.2.6 | ATP | - |
Escherichia coli | |
6.3.2.6 | ATP | - |
Homo sapiens | |
6.3.2.6 | ATP | - |
Thermotoga maritima | |
6.3.2.6 | ATP | - |
Saccharomyces cerevisiae |