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Literature summary extracted from

  • Schramm, M.; Herz, J.; Haas, A.; Kroenke, M.; Utermoehlen, O.
    Acid sphingomyelinase is required for efficient phago-lysosomal fusion (2008), Cell. Microbiol., 10, 1839-1853.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.12 endosome localizes to the lumen of endosomes Mus musculus 5768
-
3.1.4.12 lysosome localizes to the lumen of lysosomes Mus musculus 5764
-
3.1.4.12 phagosome localizes to the lumen of phagosomes Mus musculus
-
-
3.1.4.12 plasma membrane localizes to the outer leaflet of the plasma membrane Mus musculus 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 additional information Mus musculus ASMase activity is required for an efficient fusion of late phagosomes with lysosomes including the efficient transfer of lysosomal hydrolases into phagosomes containing Listeria monocytogenes ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 macrophage
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 additional information ASMase activity is required for an efficient fusion of late phagosomes with lysosomes including the efficient transfer of lysosomal hydrolases into phagosomes containing Listeria monocytogenes Mus musculus ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Mus musculus N-acylsphingosine + choline phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.12 acid sphingomyelinase
-
 Mus musculus
3.1.4.12 aSMase
-
 Mus musculus