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Literature summary extracted from

  • Nagasaki, A.; Inotsume, K.; Kanada, M.; Uyeda, T.Q.
    Phospholipase D is essential for keratocyte-like migration of NBT-II cells (2008), Cell Struct. Funct., 33, 27-33.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
3.1.4.4 additional information depletion of both PLD1 and PLD2 isoenzymes using shRNA reduces the velocity of the migration, but depletion of PLD2 inhibits motility more severly than that of PLD1 Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.4 additional information n-butanol completely blocks the migration of NBT-II cells on collagen-coated substrates and disturbes the characteristic localization of actin along edge of lamellipodia Rattus norvegicus
3.1.4.4 n-butanol n-butanol completely blocks the migration of NBT-II cells on collagen-coated substrates and disturbes the characteristic localization of actin along edge of lamellipodia Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 cytoplasmic vesicle using a GFP-PLD1 fusion protein PLD1 localizes intensely to intracellular vesicular compartments in the cell bodies and at zones along the edge of the large lamellipodia Rattus norvegicus 31410
-
3.1.4.4 lamellipodium using a GFP-PLD2 fusion protein PLD2 is localized to the protruding regions of lamellipodia in migrating cells Rattus norvegicus 30027
-

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Rattus norvegicus P70496
-
-
3.1.4.4 Rattus norvegicus P70498
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 NBT-II cell
-
 Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
3.1.4.4 phospholipase D
-
 Rattus norvegicus
3.1.4.4 PLD1
-
 Rattus norvegicus
3.1.4.4 PLD2
-
 Rattus norvegicus