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Literature summary extracted from

  • Winger, J.A.; Derbyshire, E.R.; Lamers, M.H.; Marletta, M.A.; Kuriyan, J.
    The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase (2008), BMC Struct. Biol., 8, 42.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 additional information guanylate cyclase activation mechanism, overview Chlamydomonas reinhardtii
4.6.1.2 NO
-
 Chlamydomonas reinhardtii

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.6.1.2 gene CYG12 encodes the soluble isozyme Chlamydomonas reinhardtii

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
4.6.1.2 isolated dimeric and inactive catalytic domain, X-ray diffraction structure determination and analysis at 2.55 A resolution Chlamydomonas reinhardtii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.6.1.2 additional information
-
 additional information the soluble enzyme has two active sites in the dimer exhibiting positive cooperativity with a Hill coefficient of about 1.5 Chlamydomonas reinhardtii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 soluble soluble guanylate cyclase Chlamydomonas reinhardtii
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
4.6.1.2 Mn2+ most effective, Mg2+ activates to 1% of the activity with Mn2+ Chlamydomonas reinhardtii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Chlamydomonas reinhardtii
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Chlamydomonas reinhardtii Q5YLC2 soluble isozyme; gene CYG12 encoding the soluble isozyme
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Chlamydomonas reinhardtii 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 additional information structure-function relationship, mechanism, modelling, overview Chlamydomonas reinhardtii ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.6.1.2 dimer catalytic domain, crystal structure, structure analysis and comparison, e.g. of helix alpha1, modelling, overview Chlamydomonas reinhardtii

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 soluble guanylate cyclase
-
 Chlamydomonas reinhardtii

Cofactor

EC Number Cofactor Comment Organism Structure
4.6.1.2 heme in soluble guanylate cyclases Chlamydomonas reinhardtii