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Literature summary extracted from

  • Okajima, T.; Reddy, B.; Matsuda, T.; Irvine, K.D.
    Contributions of chaperone and glycosyltransferase activities of O-fucosyltransferase 1 to Notch signaling (2008), BMC Biol., 6, 1-10.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.1.221 molecular biology O-fucosylation is dispensable for many Notch signaling events during Drosophila development Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.4.1.221 R254A expression of a mutant, Ofut1R245A, lacking fucosyltransferase activity, rescues the requirement for Ofut1 in embryonic neurogenesis. Lack of requirement for O-fucosylation is further supported by the absence of embryonic phenotypes in Gmd mutants, which lack all forms of fucosylation. Requirements for O-fucose during imaginal development are evaluated by characterizing clones of cells expressing only Ofut1R245A. These clones phenocopy fringe mutant clones, indicating that the absence of O-fucose is functionally equivalent to the absence of elongated O-fucose Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.222 additional information Drosophila melanogaster transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.221 Drosophila melanogaster
-
-
-
2.4.1.222 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.222 wing
-
 Drosophila melanogaster
-
2.4.1.222 wing disc
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.222 additional information transfers a beta-D-GlcNAc residue from UDP-D-GlcNAc to the fucose residue of a fucosylated protein acceptor Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.221 O-fucosyltransferase 1
-
 Drosophila melanogaster
2.4.1.221 OFUTI
-
 Drosophila melanogaster
2.4.1.222 FNG
-
 Drosophila melanogaster
2.4.1.222 N-acetylglucosaminyltransferase
-
 Drosophila melanogaster