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Literature summary extracted from

  • Palmer, C.D.; Mutch, B.E.; Workman, S.; McDaid, J.P.; Horwood, N.J.; Foxwell, B.M.
    Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkappaB activity (2008), Blood, 111, 1781-1788.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.2 lipopolysaccharide
-
 Homo sapiens

Application

EC Number Application Comment Organism
2.7.10.2 medicine the results have important implications for the design of therapeutics targeted against specific cytokines and their regulators in inflammatory disease Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.10.2 recombinant, replication-deficient adenoviral constructs encoding wild-type human Bmx and HA-tagged Bmx are prepared Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.10.2 RNAi knockdown of Btk results in decreased tumor necrosis factor-alpha Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine Homo sapiens
-
 ADP + [protein]-L-tyrosine phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.2 Homo sapiens
-
-
-
2.7.10.2 Homo sapiens P51813
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.2 macrophage
-
 Homo sapiens
-
2.7.10.2 monocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.10.2 ATP + [protein]-L-tyrosine
-
 Homo sapiens ADP + [protein]-L-tyrosine phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.10.2 Bmx tyrosine kinase
-
 Homo sapiens
2.7.10.2 Btk tyrosine kinase
-
 Homo sapiens