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Literature summary extracted from

  • Satomi, Y.; Ohara, K.; Yazaki, K.; Ito, M.; Honda, G.; Nishino, H.
    Production of the monoterpene limonene and modulation of apoptosis-related proteins in embryonic-mouse NIH 3T3 fibroblast cells by introduction of the limonene synthase gene isolated from Japanese catnip (Schizonepeta tenuifolia) (2009), Biotechnol. Appl. Biochem., 52, 185-190.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.2.3.20 drug development D-limonene is effective in cancer prevention in animal cancer models, some clinical applications have been performed Nepeta tenuifolia

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.2.3.20 expressed in NIH 3T3 cell Nepeta tenuifolia
4.2.3.20 The cDNA of D-limonene synthase obtained from Japanese catnip, modified by deletion of the transit peptide sequence and addition of a new ATG initiation codon, is cloned. Establishment of transgenic mouse embryonic NIH 3T3 fibroblast cells that produce limonene by introducing the D-limonene synthase gene. Apoptosis is not observed in the limonene-producing cells. Nepeta tenuifolia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.2.3.20 geranyl diphosphate Nepeta tenuifolia single step in plants D-limonene + diphosphate D-limonene shows cancer preventative and cancer therapeutic activities in vitro and in vivo, its modulates apoptosis-related genes and proteins in cultured cells ?

Organism

EC Number Organism UniProt Comment Textmining
4.2.3.20 Nepeta tenuifolia Q9FUW5
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4.2.3.20 Nepeta tenuifolia Q9FUW5 production of the monoterpene limonene and modulation of apoptosis-related proteins in embryonic-mouse NIH 3T3 fibroblast cells by introduction of the limonene synthase gene isolated from japanese catnip
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.2.3.20 cell culture
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 Nepeta tenuifolia
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.2.3.20 geranyl diphosphate single step in plants Nepeta tenuifolia D-limonene + diphosphate D-limonene shows cancer preventative and cancer therapeutic activities in vitro and in vivo, its modulates apoptosis-related genes and proteins in cultured cells ?
4.2.3.20 additional information a concomitant increase in the level of apoptosis-related protein B-cell lymphoma protein 2 and decreases in the levels of Bcl-2 antagonist of cell death and phosphorylated c-Jun N-terminal kinase are observed in limonene-producing cells Nepeta tenuifolia ?
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 ?
4.2.3.20 additional information limonene can be synthesized in animal cells using their own mevalonate pathway and limonene-producing cells may provide a new system for the elucidation of limonene function Nepeta tenuifolia ?
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 ?

Synonyms

EC Number Synonyms Comment Organism
4.2.3.20 d-limonene synthase
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 Nepeta tenuifolia
4.2.3.20 limonene synthase
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 Nepeta tenuifolia