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Literature summary extracted from

  • Hassan, M.; Okada, M.; Ichiyanagi, T.; Mori, N.
    4-N-trimethylaminobutyraldehyde dehydrogenase: purification and characterization of an enzyme from Pseudomonas sp. 13CM (2008), Biosci. Biotechnol. Biochem., 72, 155-162.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.47 1,10-phenanthroline 1 mM causes 5% inhibition at 30°C Pseudomonas sp.
1.2.1.47 3-methylbutyraldehyde 1 mM causes 57% inhibition at 30°C Pseudomonas sp.
1.2.1.47 4-N-trimethylaminobutyraldehyde the substrate inhibits at 0.24 mM Pseudomonas sp.
1.2.1.47 5,5'-dithiobis-(2-nitrobenzoic acid) 0.1 mM causes 100% inhibition at 30°C Pseudomonas sp.
1.2.1.47 acetaldehyde 1 mM causes 18% inhibition at 30°C Pseudomonas sp.
1.2.1.47 Ba2+ 1 mM causes 30% inhibition at 30°C Pseudomonas sp.
1.2.1.47 Betaine aldehyde 1 mM causes 41% inhibition at 30°C Pseudomonas sp.
1.2.1.47 Co2+ 1 mM causes 18% inhibition at 30°C Pseudomonas sp.
1.2.1.47 Cu2+ 0.05 mM causes 36% inhibition at 30°C Pseudomonas sp.
1.2.1.47 diethylmethylamine at 30°C, 5 mM causes 53% inhibition, does not inhibit at 1 mM Pseudomonas sp.
1.2.1.47 dimethylethylamine 5 mM causes 9% inhibition at 30°C Pseudomonas sp.
1.2.1.47 ethylmethylamine 1 mM causes 20% inhibition at 30°C Pseudomonas sp.
1.2.1.47 glyceraldehyde 1 mM causes 7% inhibition at 30°C Pseudomonas sp.
1.2.1.47 Hg2+ 0.05 mM causes 28% inhibition at 30°C Pseudomonas sp.
1.2.1.47 iodoacetoamide 1 mM causes 42% inhibition at 30°C Pseudomonas sp.
1.2.1.47 KCl 1 mM causes 5% inhibition at 30°C Pseudomonas sp.
1.2.1.47 Li+ 1 mM causes 13% inhibition at 30°C Pseudomonas sp.
1.2.1.47 additional information at 30°C, not inhibited by Rb+, Na+, Mg2+, Ca2+, potassium fluoride, 1 mM sodium azide, 2,2'-dipyridyl, EDTA, 1 mM trimethylamine and 1 mM tetramethylammonium chloride Pseudomonas sp.
1.2.1.47 p-chloromercuribenzoate 0.1 mM causes 88% inhibition at 30°C Pseudomonas sp.
1.2.1.47 phenylacetaldehyde 0.1 mM causes 54% inhibition at 30°C Pseudomonas sp.
1.2.1.47 Semicarbazide 1 mM causes 22% inhibition at 30°C Pseudomonas sp.
1.2.1.47 triethylamine 5 mM causes 42% inhibition at 30°C Pseudomonas sp.
1.2.1.47 trimethylacetaldehyde 1 mM causes 80% inhibition at 30°C Pseudomonas sp.
1.2.1.47 Zn2+ 1 mM causes 11% inhibition at 30°C Pseudomonas sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.47 0.0074
-
4-N-trimethylaminobutyraldehyde
-
Pseudomonas sp.
1.2.1.47 0.051
-
4-dimethylaminobutyraldehyde
-
Pseudomonas sp.
1.2.1.47 0.125
-
NAD+
-
Pseudomonas sp.

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.47 55000
-
3 * 55000, SDS-PAGE Pseudomonas sp.
1.2.1.47 160000
-
gel filtration Pseudomonas sp.

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.47 Pseudomonas sp.
-
-
-
1.2.1.47 Pseudomonas sp. 13CM
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.47 14.2fold to apparent homogeneity, by hydrophobic chromatography and affinity chromatography Pseudomonas sp.

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.47 0.8
-
cell-free extract Pseudomonas sp.
1.2.1.47 12.4
-
14.2fold purified enzyme Pseudomonas sp.

Storage Stability

EC Number Storage Stability Organism
1.2.1.47 -20°C Pseudomonas sp.

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.47 4-dimethylaminobutyraldehyde + NAD+
-
Pseudomonas sp. 4-dimethylaminobutanoate + NADH
-
?
1.2.1.47 4-dimethylaminobutyraldehyde + NAD+
-
Pseudomonas sp. 13CM 4-dimethylaminobutanoate + NADH
-
?
1.2.1.47 4-N-trimethylaminobutyraldehyde + NAD+
-
Pseudomonas sp. 4-N-trimethylaminobutanoate + NADH
-
?
1.2.1.47 4-N-trimethylaminobutyraldehyde + NAD+
-
Pseudomonas sp. 13CM 4-N-trimethylaminobutanoate + NADH
-
?
1.2.1.47 additional information does not degradate 4-trimethylaminobutanol, betaine aldehyde, 4-aminobutyraldehyde, acetaldehyde, propionaldehyde, butyraldehyde, trimethylacetaldehyde, and 3-methylbutyraldehyde Pseudomonas sp. ?
-
?
1.2.1.47 additional information does not degradate 4-trimethylaminobutanol, betaine aldehyde, 4-aminobutyraldehyde, acetaldehyde, propionaldehyde, butyraldehyde, trimethylacetaldehyde, and 3-methylbutyraldehyde Pseudomonas sp. 13CM ?
-
?

Subunits

EC Number Subunits Comment Organism
1.2.1.47 trimer 3 * 55000, SDS-PAGE Pseudomonas sp.

Synonyms

EC Number Synonyms Comment Organism
1.2.1.47 4-N-trimethylaminobutyraldehyde dehydrogenase
-
Pseudomonas sp.

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.2.1.47 40
-
-
Pseudomonas sp.

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.2.1.47 30
-
the enzyme is rapidly inactivated at temperatures above 35°C Pseudomonas sp.

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.47 10
-
-
Pseudomonas sp.

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.2.1.47 8 9 the enzyme is completely inactivated at pH 9.6 Pseudomonas sp.

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.47 additional information does not react with NADP+ Pseudomonas sp.
1.2.1.47 NAD+ is specific for NAD+ Pseudomonas sp.

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.2.1.47 Pseudomonas sp. isoelectric focusing
-
5.5