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Literature summary extracted from

  • Bojarova, P.; Williams, S.J.
    Aryl sulfamates are broad spectrum inactivators of sulfatases: effects on sulfatases from various sources (2009), Bioorg. Med. Chem. Lett., 19, 477-480.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.2 17-oxoestra-1,3,5(10)-trien-3-yl sulfamate
-
 Haliotis sp.
3.1.6.2 17-oxoestra-1,3,5(10)-trien-3-yl sulfamate
-
 Helix pomatia
3.1.6.2 17-oxoestra-1,3,5(10)-trien-3-yl sulfamate
-
 Patella vulgata
3.1.6.2 3-nitrophenyl sulfamate
-
 Haliotis sp.
3.1.6.2 3-nitrophenyl sulfamate
-
 Helix pomatia
3.1.6.2 3-nitrophenyl sulfamate
-
 Patella vulgata
3.1.6.2 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate
-
 Haliotis sp.
3.1.6.2 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate
-
 Helix pomatia
3.1.6.2 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate
-
 Patella vulgata
3.1.6.2 phosphate abalone sulfatases is inhibited by phosphate buffer: 15% activity in 5 mM K2HPO4/KH2PO4, pH 7 Haliotis sp.
3.1.6.2 phosphate limpet sulfatase is inhibited by phosphate buffer: 4% activity in 5 mM K2HPO4/KH2PO4, pH 7 Patella vulgata

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.6.2 2.03
-
 4-nitrophenyl sulfate
-
 Helix pomatia
3.1.6.2 10
-
 4-nitrophenyl sulfate
-
 Patella vulgata
3.1.6.2 10.2
-
 4-nitrophenyl sulfate
-
 Haliotis sp.

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.2 Haliotis sp.
-
 abalone entrails
-
3.1.6.2 Helix pomatia
-
-
-
3.1.6.2 Patella vulgata
-
 keyhole limpet
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.2 4-nitrophenyl sulfate + H2O
-
 Helix pomatia 4-nitrophenol + sulfate
-
 ?
3.1.6.2 4-nitrophenyl sulfate + H2O
-
 Patella vulgata 4-nitrophenol + sulfate
-
 ?
3.1.6.2 4-nitrophenyl sulfate + H2O
-
 Haliotis sp. 4-nitrophenol + sulfate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.6.2 estrone sulfatase
-
 Helix pomatia
3.1.6.2 estrone sulfatase
-
 Patella vulgata
3.1.6.2 estrone sulfatase
-
 Haliotis sp.

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.6.2 0.035
-
 3-nitrophenyl sulfamate
-
 Helix pomatia
3.1.6.2 0.98
-
 3-nitrophenyl sulfamate
-
 Patella vulgata
3.1.6.2 1.6
-
 3-nitrophenyl sulfamate
-
 Haliotis sp.