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Literature summary extracted from

  • Heynekamp, J.J.; Hunsaker, L.A.; Vander Jagt, T.A.; Royer, R.E.; Deck, L.M.; Vander Jagt, D.L.
    Isocoumarin-based inhibitors of pancreatic cholesterol esterase (2008), Bioorg. Med. Chem., 16, 5285-5294.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 3-(2-bromoethoxy)-4-chloro-7-nitro-1H-isochromen-1-one
-
 Sus scrofa
3.1.1.13 3-(2-bromoethoxy)-7-nitro-1H-isochromen-1-one
-
 Sus scrofa
3.1.1.13 3-(2-cyclohexylethoxy)-4-trifluoroacetylisocoumarin
-
 Sus scrofa
3.1.1.13 3-(2-cyclohexylethoxy)-7-nitroisocoumarin
-
 Sus scrofa
3.1.1.13 3-(3-bromopropoxy)-4-chloro-7-nitro-1H-isochromen-1-one
-
 Sus scrofa
3.1.1.13 3-(3-bromopropoxy)-7-nitro-1H-isochromen-1-one
-
 Sus scrofa
3.1.1.13 3-butoxy-4-chloroisocoumarin
-
 Sus scrofa
3.1.1.13 3-cyclohexylmethoxy-7-nitroisocoumarin
-
 Sus scrofa
3.1.1.13 3-cyclohexylmethyl-4-(trifluoroacetyl)isocoumarin
-
 Sus scrofa
3.1.1.13 3-propoxy-4-(trifluoroacetyl)isocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-(2-cyclohexylethoxy)-7-nitroisocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-(2-cyclohexylethoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-(2-cyclopentylethoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-(3-cyclohexylpropoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-(3-cyclopentylpropoxy)isocoumarin potent reversible inhibitor Sus scrofa
3.1.1.13 4-chloro-3-(4-cyclohexylbutoxy)isocoumarin potent reversible inhibitor Sus scrofa
3.1.1.13 4-chloro-3-(4-cyclohexylcyclohexyloxy)isocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-(5-cyclohexylpentoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-(cyclohexylmethoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-(cyclopentylmethoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-(cyclopentyloxy)isocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-cyclohexylmethoxy-7-nitroisocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-methoxy-7-nitroisocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-3-propoxyisocoumarin
-
 Sus scrofa
3.1.1.13 4-chloro-7-cyclohexanecarboxamide-3-methoxyisocoumarin
-
 Sus scrofa
3.1.1.13 7-amino-3-(2-bromoethoxy)-4-chloro-1H-isochromen-1-one
-
 Sus scrofa
3.1.1.13 7-amino-3-(2-bromoethoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 7-amino-4-chloro-3-methoxyisocoumarin
-
 Sus scrofa
3.1.1.13 7-benzamido-4-chloro-3-methoxyisocoumarin
-
 Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 pancreas
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl linoleate + H2O
-
 Sus scrofa cholesterol + linoleate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 bile salt-dependent lipase
-
 Sus scrofa
3.1.1.13 bile salt-stimulated lipase
-
 Sus scrofa
3.1.1.13 Carboxyl ester lipase
-
 Sus scrofa
3.1.1.13 CEase
-
 Sus scrofa
3.1.1.13 nonspecific lipase
-
 Sus scrofa
3.1.1.13 pancreatic cholesterol esterase
-
 Sus scrofa
3.1.1.13 Pancreatic lysophospholipase
-
 Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.1.13 0.000011
-
 4-chloro-3-(4-cyclohexylbutoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 0.000019
-
 4-chloro-3-(3-cyclopentylpropoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 0.00018
-
 4-chloro-3-(3-cyclohexylpropoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 0.00019
-
 4-chloro-3-(4-cyclohexylcyclohexyloxy)isocoumarin
-
 Sus scrofa
3.1.1.13 0.00026
-
 4-chloro-3-(2-cyclopentylethoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 0.00036
-
 4-chloro-3-(cyclopentylmethoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 0.0007
-
 4-chloro-3-(2-cyclohexylethoxy)-7-nitroisocoumarin
-
 Sus scrofa
3.1.1.13 0.00095
-
 4-chloro-3-(cyclopentyloxy)isocoumarin
-
 Sus scrofa
3.1.1.13 0.0012
-
 4-chloro-3-(4-cyclohexylbutoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 0.0012
-
 4-chloro-3-(2-cyclohexylethoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 0.0018
-
 4-chloro-3-(cyclohexylmethoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 0.0036
-
 4-chloro-3-propoxyisocoumarin
-
 Sus scrofa
3.1.1.13 0.0057
-
 4-chloro-3-cyclohexylmethoxy-7-nitroisocoumarin
-
 Sus scrofa
3.1.1.13 0.0065
-
 3-butoxy-4-chloroisocoumarin
-
 Sus scrofa
3.1.1.13 0.017
-
 7-amino-4-chloro-3-methoxyisocoumarin
-
 Sus scrofa
3.1.1.13 0.019
-
 4-chloro-3-methoxy-7-nitroisocoumarin
-
 Sus scrofa
3.1.1.13 0.025
-
 3-propoxy-4-(trifluoroacetyl)isocoumarin Ki above 0.025 mM Sus scrofa
3.1.1.13 0.025
-
 4-chloro-7-cyclohexanecarboxamide-3-methoxyisocoumarin Ki above 0.025 mM Sus scrofa
3.1.1.13 0.054
-
 3-cyclohexylmethoxy-7-nitroisocoumarin
-
 Sus scrofa
3.1.1.13 0.062
-
 4-chloro-3-(5-cyclohexylpentoxy)isocoumarin
-
 Sus scrofa
3.1.1.13 0.073
-
 3-(2-cyclohexylethoxy)-4-trifluoroacetylisocoumarin
-
 Sus scrofa
3.1.1.13 0.1
-
 3-cyclohexylmethyl-4-(trifluoroacetyl)isocoumarin Ki above 0.1 mM Sus scrofa
3.1.1.13 0.1
-
 3-(2-cyclohexylethoxy)-7-nitroisocoumarin Ki above 0.1 mM Sus scrofa
3.1.1.13 0.1
-
 7-amino-3-(2-bromoethoxy)isocoumarin Ki above 0.1 mM Sus scrofa
3.1.1.13 0.25
-
 7-benzamido-4-chloro-3-methoxyisocoumarin Ki above 0.25 mM Sus scrofa