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Literature summary extracted from

  • Schwab, F.; van Gunsteren, W.F.; Zagrovic, B.
    Computational study of the mechanism and the relative free energies of binding of anticholesteremic inhibitors to squalene-hopene cyclase (2008), Biochemistry, 47, 2945-2951.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.99.17 6-[[3-(4-bromophenyl)-1,2-benzisoxazol-6-yl]oxy]-N-methyl-N-prop-2-en-1-ylhexan-1-amine
-
 Alicyclobacillus acidocaldarius
5.4.99.17 6-[[3-(4-bromophenyl)-1-benzofuran-6-yl]oxy]-N-methyl-N-prop-2-en-1-ylhexan-1-amine
-
 Alicyclobacillus acidocaldarius
5.4.99.17 6-[[3-(4-bromophenyl)-1-methyl-1H-indol-6-yl]oxy]-N-methyl-N-prop-2-en-1-ylhexan-1-amine
-
 Alicyclobacillus acidocaldarius
5.4.99.17 6-[[3-(4-bromophenyl)-1H-indazol-6-yl]oxy]-N-methyl-N-prop-2-en-1-ylhexan-1-amine
-
 Alicyclobacillus acidocaldarius

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.4.99.17 membrane
-
 Alicyclobacillus acidocaldarius 16020
-

Organism

EC Number Organism UniProt Comment Textmining
5.4.99.17 Alicyclobacillus acidocaldarius P33247
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.99.17 squalene
-
 Alicyclobacillus acidocaldarius hop-22(29)-ene
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.4.99.17 SHC
-
 Alicyclobacillus acidocaldarius

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
5.4.99.17 0.000075
-
-
 Alicyclobacillus acidocaldarius 6-[[3-(4-bromophenyl)-1,2-benzisoxazol-6-yl]oxy]-N-methyl-N-prop-2-en-1-ylhexan-1-amine