Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rebrin, I.; Bregere, C.; Kamzalov, S.; Gallaher, T.K.; Sohal, R.S.
    Nitration of tryptophan 372 in succinyl-CoA:3-ketoacid CoA transferase during aging in rat heart mitochondria (2007), Biochemistry, 46, 10130-10144.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.3.5 mitochondrion rat heart mitochondria at 4, 13, 19, and 24 months of age Rattus norvegicus 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.8.3.5 58000
-
subunits 2 * 58000, SDS-PAGE, immunostaining and Coomassie Blue Rattus norvegicus
2.8.3.5 120000
-
SDS-PAGE, immunostaining and Coomassie Blue, dimer Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.3.5 succinyl-CoA + a 3-oxo acid Rattus norvegicus
-
succinate + a 3-oxoacyl-CoA
-
?
2.8.3.5 succinyl-CoA + acetoacetate Rattus norvegicus involved in the breakdown of ketone bodies in the extrahepatic tissues, mainly heart and skeletal muscle, SCOT catalyzes the conversion of the main ketone body, acetoacetate, into acetoacetyl-CoA, which is subsequently metabolized via citric acid cycle for energy production succinate + acetoacetyl-CoA
-
r
2.8.3.5 succinyl-CoA + beta-hydroxybutyrate Rattus norvegicus
-
succinate + beta-hydroxybutyryl-CoA
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.8.3.5 Rattus norvegicus
-
Male Fisher rats of different ages
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.8.3.5 gel filtration Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.3.5 brain
-
Rattus norvegicus
-
2.8.3.5 heart
-
Rattus norvegicus
-
2.8.3.5 hindlimb skeletal muscle Rattus norvegicus
-
2.8.3.5 kidney
-
Rattus norvegicus
-
2.8.3.5 lung
-
Rattus norvegicus
-
2.8.3.5 additional information no activity in testis and liver Rattus norvegicus
-
2.8.3.5 skeletal muscle of hind limb Rattus norvegicus
-
2.8.3.5 spleen
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.3.5 succinyl-CoA + a 3-oxo acid
-
Rattus norvegicus succinate + a 3-oxoacyl-CoA
-
?
2.8.3.5 succinyl-CoA + acetoacetate involved in the breakdown of ketone bodies in the extrahepatic tissues, mainly heart and skeletal muscle, SCOT catalyzes the conversion of the main ketone body, acetoacetate, into acetoacetyl-CoA, which is subsequently metabolized via citric acid cycle for energy production Rattus norvegicus succinate + acetoacetyl-CoA
-
r
2.8.3.5 succinyl-CoA + acetoacetate here we report the novel finding that tryptophan 372, located in close vicinity of the enzyme active site, is a specific in vivo target of nitration/oxidation, and that the amount of SCOT nitration and activity increase with age Rattus norvegicus succinate + acetoacetyl-CoA
-
r
2.8.3.5 succinyl-CoA + beta-hydroxybutyrate
-
Rattus norvegicus succinate + beta-hydroxybutyryl-CoA
-
?

Synonyms

EC Number Synonyms Comment Organism
2.8.3.5 SCOT
-
Rattus norvegicus
2.8.3.5 SCOT1
-
Rattus norvegicus
2.8.3.5 succinyl-CoA:3-ketoacid coenzyme A transferase
-
Rattus norvegicus