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Literature summary extracted from

  • Mazzucco, C.E.; Hamatake, R.K.; Colonno, R.J.; Tenney, D.J.
    Entecavir for treatment of hepatitis B virus displays no in vitro mitochondrial toxicity or DNA polymerase gamma inhibition (2008), Antimicrob. Agents Chemother., 52, 598-605.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.7 adefovir diphosphate
-
 Drosophila melanogaster
2.7.7.7 lamivudine triphosphate
-
 Drosophila melanogaster
2.7.7.7 additional information no inhibition by entecavir Drosophila melanogaster
2.7.7.7 tenofovir diphosphate
-
 Drosophila melanogaster
2.7.7.7 zalcitabine triphosphate
-
 Drosophila melanogaster
2.7.7.7 zidovudine triphosphate
-
 Drosophila melanogaster

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.7.7 0.00012
-
 2'-deoxyguanosine triphosphate in 50 mM Tris-HCl (pH 7.6), 100 mM KCl, 5 mM MgCl2, 10% (v/v) glycerol, 1 mM dithiothreitol, at 30°C Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.7 mitochondrion
-
 Drosophila melanogaster 5739
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.7 Drosophila melanogaster
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.7.7 embryo
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.7 2'-deoxyguanosine triphosphate + DNAn
-
 Drosophila melanogaster diphosphate + DNAn+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.7 DNA polymerase gamma
-
 Drosophila melanogaster
2.7.7.7 Pol gamma
-
 Drosophila melanogaster