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Literature summary extracted from

  • Sandrini, M.P.; Shannon, O.; Clausen, A.R.; Bjoerck, L.; Piskur, J.
    Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria (2007), Antimicrob. Agents Chemother., 51, 2726-2732.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.76
-
 Staphylococcus aureus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.76 0.0292
-
 2'-deoxyadenosine pH 8.0 Staphylococcus aureus
2.7.1.76 0.0344
-
 2'-deoxycytidine pH 8.0 Staphylococcus aureus
2.7.1.76 0.192
-
 2',2'-difluorodesoxycytidine pH 8.0 Staphylococcus aureus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.76 26400
-
 x * 26400, calculated Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.76 Staphylococcus aureus Q0H0H0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.76 ATP + 2',2'-difluorodeoxycytidine
-
 Staphylococcus aureus ADP + 2',2'-difluorodeoxycytidine 5'-phosphate
-
 ?
2.7.1.76 ATP + 2'-deoxyadenosine
-
 Staphylococcus aureus ADP + 2'-deoxyadenosine 5'-phosphate
-
 ?
2.7.1.76 ATP + 2'-deoxycytidine
-
 Staphylococcus aureus ADP + 2'-deoxycytidine 5'-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.76 ? x * 26400, calculated Staphylococcus aureus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.1.76 0.19
-
 2',2'-difluorodeoxycytidine pH 8.0 Staphylococcus aureus
2.7.1.76 0.56
-
 2'-deoxycytidine pH 8.0 Staphylococcus aureus
2.7.1.76 1.82
-
 2'-deoxyadenosine pH 8.0 Staphylococcus aureus