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Literature summary extracted from

  • Guo, D.; Nguyen, T.; Ogbi, M.; Tawfik, H.; Ma, G.; Yu, Q.; Caldwell, R.W.; Johnson, J.A.
    Protein kinase C-epsilon coimmunoprecipitates with cytochrome oxidase subunit IV and is associated with improved cytochrome-c oxidase activity and cardioprotection (2007), Am. J. Physiol. Heart Circ. Physiol., 293, H2219-H2230.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.1.1.9 additional information ischemic preconditioning administered before prolonged ischemia-reperfusion induces a 1.9fold increase in coimmunoprecipitation of cytochrome oxidase subunit IV, with anti-PKC-epsilon antisera and a 2fold enhancement of cytochrome-c oxidase activity. Intact mitochondria show virtually no cytochrome-c oxidase activity, unless they are permeablized with n-dodecyl-beta,D-maltoside Rattus norvegicus

Application

EC Number Application Comment Organism
7.1.1.9 medicine recovery of enhanced cytochrome-c oxidase activity may play a role in ischemic preconditioning protection Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 KCN 1 mM completely inhibits Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 ferrocytochrome c + O2 + H+
-
 Rattus norvegicus ferricytochrome c + H2O
-
 ?