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Literature summary extracted from

  • Pedretti, A.; Bocci, E.; Maggi, R.; Vistoli, G.
    Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations (2008), Steroids, 73, 708-719.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
1.3.1.72 E191K decreased activity Homo sapiens
1.3.1.72 K306N decreased activity Homo sapiens
1.3.1.72 N294T decreased activity Homo sapiens
1.3.1.72 Y471S decreased activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.72 membrane DHCR24 possesses a putative transmembrane segment Homo sapiens 16020
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.72 Homo sapiens Q15392
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.72 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH
-
 Homo sapiens 4,4-dimethyl-5alpha-cholesta-8,14-dien-3beta-ol + NADP+
-
 ?
1.3.1.72 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADPH
-
 Homo sapiens 4,4-dimethyl-5alpha-cholesta-8-en-3beta-ol + NADP+
-
 ?
1.3.1.72 5alpha-cholesta-7,24-dien-3beta-ol + NADPH
-
 Homo sapiens 5alpha-cholest-7-en-3beta-ol + NADP+
-
 ?
1.3.1.72 7-dehydrodesmosterol + NADPH
-
 Homo sapiens 7-dehydrocholesterol + NADP+
-
 ?
1.3.1.72 desmosterol + FADH2
-
 Homo sapiens cholesterol + FAD + H+
-
 ?
1.3.1.72 lanosterol + NADPH + H+
-
 Homo sapiens 24-dihydrolanosterol + NADP+
-
 ?
1.3.1.72 zymosterol + NADPH
-
 Homo sapiens 5alpha-cholesta-8-en-3beta-ol + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.3.1.72 3-beta-hydroxysterol-DELTA24-reductase
-
 Homo sapiens
1.3.1.72 DHCR24 catalyzes the last step of the cholesterol biosynthesis Homo sapiens
1.3.1.72 seladin-1
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.72 NADPH
-
 Homo sapiens