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Literature summary extracted from

  • Saito, J.; Yamada, M.; Watanabe, T.; Iida, M.; Kitagawa, H.; Takahata, S.; Ozawa, T.; Takeuchi, Y.; Ohsawa, F.
    Crystal structure of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor (2008), Protein Sci., 17, 691-699.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
1.3.1.9 medicine targeting enoyl-ACP reductase is an attractive approach for the development of novel antibacterials Streptococcus pneumoniae

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.3.1.9
-
Streptococcus pneumoniae

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.3.1.9 in complex with 1, hanging drop vapour diffusion method, with 0.1 M MES, pH 5.5-7.0, 0.1 M NH4Cl, 0.2 M CaCl2, 8-15% 2-methyl-2,4-pentanediol , 8-15% polyethyleneglycol 1000, and 5 mM dithiothreitol Streptococcus pneumoniae
1.3.1.9 the crystal structure of enoyl-acyl carrier protein reductase is determined at 1.7 A, in complex with a phenylimidazole derivative inhibitor at 2.3 A Streptococcus pneumoniae

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.3.1.9 AG205
-
Streptococcus pneumoniae
1.3.1.9 methyl 2-[[(1H-benzimidazol-2-ylmethyl)carbamoyl]amino]-1,3-benzothiazole-6-carboxylate AG205 Streptococcus pneumoniae
1.3.1.9 NADH
-
Streptococcus pneumoniae
1.3.1.9 sodium (4-[2-[([[5-(pyridin-2-ylsulfanyl)-1,3-thiazol-2-yl]carbamoyl]amino)methyl]-1H-imidazol-4-yl]phenoxy)acetate competitive inhibitor with respect to NADH and uncompetitive inhibitor with respect to crotonyl-CoA Streptococcus pneumoniae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.3.1.9 0.007
-
crotonyl-CoA
-
Streptococcus pneumoniae
1.3.1.9 0.067
-
NADH
-
Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.9 additional information Streptococcus pneumoniae FabK catalyzes the reduction of enoyl-ACPs with the concomitant oxidation of NADH ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.9 Streptococcus pneumoniae
-
-
-
1.3.1.9 Streptococcus pneumoniae Q8DR17
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.3.1.9
-
Streptococcus pneumoniae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.9 crotonyl-CoA + NAD+ inhibition assay Streptococcus pneumoniae ?
-
?
1.3.1.9 crotonyl-CoA + NADH + H+
-
Streptococcus pneumoniae butyryl-CoA + NAD+
-
?
1.3.1.9 additional information FabK catalyzes the reduction of enoyl-ACPs with the concomitant oxidation of NADH Streptococcus pneumoniae ?
-
?

Subunits

EC Number Subunits Comment Organism
1.3.1.9 dimer x-ray crystallography Streptococcus pneumoniae

Synonyms

EC Number Synonyms Comment Organism
1.3.1.9 enoyl-acyl carrier protein reductase
-
Streptococcus pneumoniae
1.3.1.9 FabK
-
Streptococcus pneumoniae

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.9 7
-
inhibition assay Streptococcus pneumoniae

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.9 FMN
-
Streptococcus pneumoniae
1.3.1.9 NADH
-
Streptococcus pneumoniae

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.3.1.9 0.000011
-
sodium (4-[2-[([[5-(pyridin-2-ylsulfanyl)-1,3-thiazol-2-yl]carbamoyl]amino)methyl]-1H-imidazol-4-yl]phenoxy)acetate
-
Streptococcus pneumoniae
1.3.1.9 0.000029
-
NADH
-
Streptococcus pneumoniae