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Literature summary extracted from

  • Magid, A.A.; Voutquenne-Nazabadioko, L.; Bontemps, G.; Litaudon, M.; Lavaud, C.
    Tyrosinase inhibitors and sesquiterpene diglycosides from Guioa villosa (2008), Planta Med., 74, 55-60.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.18.1 3-O-[2,6-di-O-alpha-L-rhamnopyranosyl-beta-D-galactopyranosyl]-quercetin from Guioa villosa leaf extract Agaricus bisporus
1.14.18.1 apigenin 4'-O-beta-D-glucopyranoside from Guioa villosa leaf extract Agaricus bisporus
1.14.18.1 betulin from Guioa villosa leaf extract Agaricus bisporus
1.14.18.1 chrysoeriol 4'-O-beta-D-glucopyranoside from Guioa villosa leaf extract Agaricus bisporus
1.14.18.1 crenulatoside A from Guioa villosa leaf extract, inhibition at 5 mg/ml 23.7% Agaricus bisporus
1.14.18.1 crenulatoside B from Guioa villosa leaf extract Agaricus bisporus
1.14.18.1 crenulatoside C from Guioa villosa leaf extract Agaricus bisporus
1.14.18.1 crenulatoside D from Guioa villosa leaf extract Agaricus bisporus
1.14.18.1 epicatechin-(4beta-8, 2beta-O-7)-epicatechin-(4beta-8)-epicatechin from Guioa villosa leaf extract, inhibition at 5 mg/ml 34.6% Agaricus bisporus
1.14.18.1 kojic acid used as standard inhibitor for the tyrosinase Agaricus bisporus
1.14.18.1 lupeol from Guioa villosa leaf extract Agaricus bisporus
1.14.18.1 luteolin 4'-O-beta-D-glucopyranoside from Guioa villosa leaf extract, inhibition at 5 mg/ml 14% Agaricus bisporus
1.14.18.1 mauritianin from Guioa villosa leaf extract Agaricus bisporus
1.14.18.1 soyacerebroside I from Guioa villosa leaf extract, inhibition at 5 mg/ml 86.3% Agaricus bisporus

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.1 Agaricus bisporus
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.18.1 additional information
-
 2400 U/ml mushroom tyrosinase Agaricus bisporus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.1 L-dopa + 1/2 O2
-
 Agaricus bisporus L-dopaquinone + H2O
-
 ?
1.14.18.1 L-tyrosine + O2 + AH2
-
 Agaricus bisporus L-dopa + H2O + A
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.1 tyrosinase
-
 Agaricus bisporus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.18.1 6.8
-
 assay at Agaricus bisporus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.14.18.1 0.68
-
-
 Agaricus bisporus kojic acid
1.14.18.1 1.13
-
-
 Agaricus bisporus soyacerebroside I
1.14.18.1 1.44
-
-
 Agaricus bisporus betulin
1.14.18.1 2.24
-
-
 Agaricus bisporus lupeol